The activator/repressor Hap1 binds to the yeast eIF5A‐encoding gene TIF51A to adapt its expression to the mitochondrial functional status
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14366
Abstract: Mitochondrial activity adapts to cellular energetic and metabolic demands; its dysfunction is a hallmark of ageing and many human diseases. The evolutionarily conserved translation elongation factor eIF5A is involved in maintaining mitochondrial function. In humans,… read more here.
Keywords: functional status; repressor; mitochondrial functional; expression ... See more keywords
Immunohistochemical relationships of huntingtin-associated protein 1 with enteroendocrine cells in the pyloric mucosa of the rat stomach.
Sign Up to like & getrecommendations! Published in 2020 at "Acta histochemica"
DOI: 10.1016/j.acthis.2020.151650
Abstract: Huntingtin-associated protein 1 (HAP1) is a neuronal cytoplasmic protein that is predominantly expressed in the brain and spinal cord. In addition to the central nervous system, HAP1 is also expressed in the peripheral organs including… read more here.
Keywords: protein; associated protein; huntingtin associated; hap1 ... See more keywords
Efficient and crucial quality control of HAP1 cell ploidy status
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DOI: 10.1242/bio.057174
Abstract: ABSTRACT The near-haploid human cell line HAP1 recently became a popular subject for CRISPR/Cas9 editing, since only one allele requires modification. Through the gene-editing service at Horizon Discovery, there are at present more than 7500… read more here.
Keywords: ploidy; hap1; ploidy status; quality control ... See more keywords
Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response
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DOI: 10.3389/fncel.2020.00125
Abstract: Huntingtin-associated protein 1 (Hap1) was initially identified as a brain-enriched protein that binds to the Huntington’s disease protein, huntingtin. Unlike huntingtin that is ubiquitously expressed in the brain, Hap1 is enriched in the brain with… read more here.
Keywords: huntingtin; hap1; stress response; hypothalamus ... See more keywords
Immunohistochemical Distribution and Neurochemical Characterization of Huntingtin-Associated Protein 1 Immunoreactive Neurons in the Adult Mouse Lingual Ganglia
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DOI: 10.3390/brainsci13020258
Abstract: Huntingtin-associated protein 1 (HAP1) is a determinant marker for the stigmoid body (STB), a neurocytoplasmic physiological inclusion. STB/HAP1 enriched areas in the brain/spinal cord are usually protected from neurodegenerative diseases, whereas the regions with tiny… read more here.
Keywords: hap1; huntingtin associated; lingual ganglia; immunohistochemical distribution ... See more keywords