MIR17HG polymorphisms contribute to high-altitude pulmonary edema susceptibility in the Chinese population
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DOI: 10.1038/s41598-022-06944-8
Abstract: High-altitude pulmonary edema (HAPE) is a common acute altitude sickness. This study was designed to investigate the effect of MIR17HG polymorphisms on HAPE risk in the Chinese population. The Agena MassARRAY platform was used to… read more here.
Keywords: risk; mir17hg; chinese population; mir17hg polymorphisms ... See more keywords
Respiratory tract infection: an unfamiliar risk factor in high-altitude pulmonary edema.
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elac048
Abstract: The dramatic changes in physiology at high altitude (HA) as a result of the characteristic hypobaric hypoxia condition can modify innate and adaptive defense mechanisms of the body. As a consequence, few sojourners visiting HA… read more here.
Keywords: infection; risk; respiratory tract; high altitude ... See more keywords
Effects of acetazolamide on pulmonary artery pressure and prevention of high altitude pulmonary edema after rapid active ascent to 4,559 m.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00806.2021
Abstract: Acetazolamide prevents acute mountain sickness (AMS) by inhibition of carbonic anhydrase. Since it reduces acute hypoxic pulmonary vasoconstriction (HPV), it may also prevent high-altitude pulmonary edema (HAPE) by lowering pulmonary artery pressure. We tested this… read more here.
Keywords: artery pressure; high altitude; pulmonary artery; altitude ... See more keywords
Expression of Aquaporin-1 and Aquaporin-5 in a Rat Model of High-Altitude Pulmonary Edema and the Effect of Hyperbaric Oxygen Exposure
Sign Up to like & getrecommendations! Published in 2020 at "Dose-Response"
DOI: 10.1177/1559325820970821
Abstract: Objective: To investigate the therapeutic roles of hyperbaric oxygen exposure on high-altitude pulmonary edema and to determine whether aquaporin-1 and aquaporin-5 were involved in the pathogenesis of HAPE in rats. Methods: Rats were divided into… read more here.
Keywords: oxygen exposure; hape; exposure; group ... See more keywords
Clinical and experimental phenotype of azole-resistant Aspergillus fumigatus with a HapE splice site mutation: a case report
Sign Up to like & getrecommendations! Published in 2021 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-021-06279-1
Abstract: Background The recent increase in cases of azole-resistant Aspergillus fumigatus (AR Af ) infections is a major clinical concern owing to its treatment limitations. Patient-derived AR Af occurs after prolonged azole treatment in patients with… read more here.
Keywords: hape; treatment; case; azole resistant ... See more keywords
Association of variants m.T16172C and m.T16519C in whole mtDNA sequences with high altitude pulmonary edema in Han Chinese lowlanders
Sign Up to like & getrecommendations! Published in 2022 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-021-01791-1
Abstract: Background High altitude pulmonary edema (HAPE) is a hypoxia-induced non-cardiogenic pulmonary edema that typically occurred in un-acclimatized lowlanders, which inevitably leads to life-threatening consequences. Apart from multiple factors involved, the genetic factors also play an… read more here.
Keywords: non hape; pulmonary edema; hape patients; hape ... See more keywords
Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280136
Abstract: High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms… read more here.
Keywords: gene polymorphisms; risk; hape; cyp4f2 gene ... See more keywords
Association between single nucleotide polymorphisms in ADRB2, GNB3 and GSTP1 genes and high-altitude pulmonary edema (HAPE) in the Chinese Han population
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DOI: 10.18632/oncotarget.15309
Abstract: High altitude pulmonary edema (HAPE) occurs mainly under conditions such as high altitude, rapid ascent, or hypoxia. Previous studies suggest that ADRB2, GNB3, TH, and GSTP1 polymorphisms are associated with various lung diseases. We evaluated… read more here.
Keywords: risk hape; hape; gstp1; gnb3 gstp1 ... See more keywords
Association Between the Polymorphism of Steroid Hormone Metabolism Genes and High-Altitude Pulmonary Edema in the Chinese Han Population
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s345495
Abstract: Purpose Steroid hormone metabolism plays an essential role in high-altitude pulmonary edema (HAPE) progression. This study aimed to investigate the association between polymorphism in seven steroid hormone metabolism genes (STAR, HSD3B1, HSD3B2, CYP17A1, CYP21A2, CYP11B1,… read more here.
Keywords: hape; high altitude; steroid hormone; hormone metabolism ... See more keywords
Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1155414
Abstract: Backgrounds: High-altitude pulmonary edema (HAPE) is a life-threatening disease without effective drugs. Caffeine is a small molecule compound with antioxidant biological activity used to treat respiratory distress syndrome. However, it is unclear whether caffeine plays… read more here.
Keywords: quality; control; caffeine; pulmonary edema ... See more keywords
The EDN1 Missense Variant rs5370G > T Regulates Adaptation and Maladaptation under Hypobaric Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph191811174
Abstract: Endothelin 1 (EDN1) encodes a potent endogenous vasoconstrictor, ET1, to maintain vascular homeostasis and redistribution of tissue blood flow during exercise. One of the EDN1 missense polymorphisms, rs5370 G/T, has strongly been associated with cardiopulmonary… read more here.
Keywords: edn1; physiology; adaptation maladaptation; edn1 missense ... See more keywords