Using Functional Genetics in Haploid Cells for Drug Target Identification.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9145-7_1
Abstract: Pooled genetic screens are a powerful tool to identify targets for drug development as well as chemogenetic interactions. Various complementary methods for mutagenesis are available to generate highly complex cell populations, including mRNA knockdown, directed… read more here.
Keywords: genetics; using functional; drug; haploid cells ... See more keywords
The milestone of genetic screening: Mammalian haploid cells
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.09.006
Abstract: Mammalian haploid cells provide insights into multiple genetics approaches as have been proved by advances in homozygous phenotypes and function as gametes. Recent achievements make ploidy of mammalian haploid cells stable and improve the developmental… read more here.
Keywords: genetic screening; milestone genetic; mammalian haploid; genetics ... See more keywords
In vivo autophagy and biogenesis of autophagosomes within male haploid cells during spermiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18221
Abstract: Autophagy is a unique catabolic pathway that is linked to several physiological processes. However, its role in the process of spermiogenesis is largely unknown. The aim of the current study was to determine the in… read more here.
Keywords: spermiogenesis; biogenesis; within male; haploid cells ... See more keywords
Hungry for Sex: Differential Roles for Ustilago maydis b Locus Components in Haploid Cells vis à vis Nutritional Availability
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fungi"
DOI: 10.3390/jof7020135
Abstract: Mating-types allow single-celled eukaryotic organisms to distinguish self from non-self in preparation for sexual reproduction. The components of mating-type loci provide initial self/non-self-recognition through pheromone and receptor interactions that control early cell fusion events. However,… read more here.
Keywords: transcription; ustilago maydis; haploid cells; roles haploid ... See more keywords