Depletion of αβ+ T cells for a haploidentical hematopoietic stem cell transplantation in children
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21634
Abstract: A consistent and reproducible depletion technique is crucial for the successful transplantation of an ex vivo depleted graft. Our aim was to evaluate the efficacy of an ex vivo technique for depletion of αβ+ T… read more here.
Keywords: depletion cells; haploidentical hematopoietic; transplantation; hematopoietic stem ... See more keywords
Risk factors in patients undergoing haploidentical hematopoietic stem cell transplantation for high-risk childhood acute leukemia
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hematology"
DOI: 10.1007/s12185-017-2317-y
Abstract: In the present study, we sought to analyze the risk factors following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in children with high-risk acute leukemia. We retrospectively reviewed data from 73 children with high-risk leukemia. Univariate… read more here.
Keywords: risk; haploidentical hematopoietic; high risk; risk factors ... See more keywords
Outcomes of Acute Myelogenous Leukemia Patients Undergoing Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide: Impact of Total Body Irradiation Versus Chemotherapy-Based Myeloablative Conditioning
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.618
Abstract: Background Optimal myeloablative conditioning (MAC) in the setting of haploidentical hematopoietic cell transplantation (haplo-HCT) with post-transplant cyclophosphamide (PTCy) is unknown. We studied the outcomes of total body irradiation (TBI) vs. chemotherapy (CT) based MAC regimens… read more here.
Keywords: haplo hct; haploidentical hematopoietic; cell transplantation; hematopoietic cell ... See more keywords
New Strategy of Acute Graft-vs-Host Disease: Investigation of a Reduced Dose of Antithymocyte Globulin in Haploidentical Hematopoietic Stem Cell Transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.10.028
Abstract: Graft-vs-host disease (GVHD) is one of the biggest challenges in haploidentical hematopoietic stem cell transplantation. Antithymocyte globulins (ATGs) are widely used to overcome GVHD, but excessive immunosuppression increases the chances of relapse and infection following… read more here.
Keywords: stem cell; haploidentical hematopoietic; reduced dose; transplantation ... See more keywords
Impact of CD34+ cell dose on reduced intensity conditioning regimen haploidentical hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Haematology"
DOI: 10.1111/ejh.13332
Abstract: Haploidentical hematopoietic stem cell transplant (haplo‐SCT) has been associated with higher rates of graft rejection, and a higher dose of CD34+ cell dose is frequently requested. We aim to explore the impact of CD34+ cell… read more here.
Keywords: cd34 cell; haploidentical hematopoietic; stem cell; cell dose ... See more keywords
Adenovirus infection diagnosed by metagenomic next‐generation sequencing after haploidentical hematopoietic stem cell transplantation: A multicenter study in China
Sign Up to like & getrecommendations! Published in 2023 at "Transplant Infectious Disease"
DOI: 10.1111/tid.14054
Abstract: This study aims to observe and analyze the clinical characteristics and prognosis of adenovirus (ADV) infection diagnosed by metagenomic next‐generation sequencing (mNGS) after haploidentical hematopoietic stem cell transplantation (Haplo‐HSCT), which was performed following Beijing Protocol. read more here.
Keywords: infection diagnosed; haploidentical hematopoietic; diagnosed metagenomic; next generation ... See more keywords
Selected memory T cells infused post haploidentical hematopoietic stem cell transplantation persist and hyper-expand.
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DOI: 10.1182/bloodadvances.2022007735
Abstract: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with post-transplant cyclophosphamide is a curative treatment for many hematological malignancies, yet a majority of patients still suffers from recurrent infections. Post-transplant infusion of memory T cells could potentially… read more here.
Keywords: cell; stem cell; haploidentical hematopoietic; hematopoietic stem ... See more keywords
Mechanisms of Leukemia Immune Evasion and Their Role in Relapse After Haploidentical Hematopoietic Cell Transplantation
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DOI: 10.3389/fimmu.2020.00147
Abstract: Over the last decade, the development of multiple strategies to allow the safe transfer from the donor to the patient of high numbers of partially HLA-incompatible T cells has dramatically reduced the toxicities of haploidentical… read more here.
Keywords: haplo hct; haploidentical hematopoietic; cell transplantation; relapse ... See more keywords
Lower dose of ATG combined with basiliximab for haploidentical hematopoietic stem cell transplantation is associated with effective control of GVHD and less CMV viremia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1017850
Abstract: Currently, the graft-versus-host disease (GVHD) prophylaxis consists of an immunosuppressive therapy mainly based on antithymocyte globulin (ATG) or post-transplant cyclophosphamide (PTCy). GVHD remains a major complication and limitation to successful allogeneic haploidentical hematopoietic stem cell… read more here.
Keywords: dose atg; gvhd prophylaxis; haploidentical hematopoietic; gvhd ... See more keywords
Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1064190
Abstract: Background Prognosis of children with primary disseminated or metastatic relapsed sarcomas remains dismal despite intensification of conventional therapies including high-dose chemotherapy. Since haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is effective in the treatment of hematological… read more here.
Keywords: stem cell; haploidentical hematopoietic; patients high; cell transplantation ... See more keywords