Developmental disorders caused by haploinsufficiency of transcriptional regulators: a perspective based on cell fate determination
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DOI: 10.1242/bio.058896
Abstract: ABSTRACT Many human birth defects and neurodevelopmental disorders are caused by loss-of-function mutations in a single copy of transcription factor (TF) and chromatin regulator genes. Although this dosage sensitivity has long been known, how and… read more here.
Keywords: disorders caused; cell fate; transcriptional regulators; biology ... See more keywords