The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters
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DOI: 10.1093/nar/gkx218
Abstract: Abstract One third of tumor suppressors are haploinsufficient transcriptional regulators, yet it remains unknown how a 50% reduction of a transcription factor is translated at the cis-regulatory level into a malignant transcriptional program. We studied… read more here.
Keywords: haploinsufficient tumor; cux1; distal enhancers; target ... See more keywords