Comparative study for haplotype block partitioning methods – Evidence from chromosome 6 of the North American Rheumatoid Arthritis Consortium (NARAC) dataset
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DOI: 10.1371/journal.pone.0209603
Abstract: Haplotype-based methods compete with “one-SNP-at-a-time” approaches on being preferred for association studies. Chromosome 6 contains most of the known genetic biomarkers for rheumatoid arthritis (RA) disease. Therefore, chromosome 6 serves as a benchmark for the… read more here.
Keywords: narac dataset; haplotype block; block; snps ... See more keywords
Linkage disequilibrium and haplotype block patterns in popcorn populations
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DOI: 10.1371/journal.pone.0219417
Abstract: Linkage disequilibrium (LD) analysis provides information on the evolutionary aspects of populations. Recently, haplotype blocks have been used to increase the power of quantitative trait loci detection in genome-wide association studies and the prediction accuracy… read more here.
Keywords: popcorn populations; haplotype; haplotype block; population ... See more keywords
Haplotype Block Analysis Reveals Candidate Genes and QTLs for Meat Quality and Disease Resistance in Chinese Jiangquhai Pig Breed
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DOI: 10.3389/fgene.2020.00752
Abstract: The Jiangquhai (JQ) pig breed is one of the most widely recognized pig populations in China due to its unique and dominant characteristics. In this study, we examined the extent of Linkage disequilibrium (LD) and… read more here.
Keywords: haplotype; pig; pig breed; haplotype block ... See more keywords
Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent
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DOI: 10.3389/fgene.2020.558762
Abstract: Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks… read more here.
Keywords: lactase persistence; haplotype block; disease; persistence haplotype ... See more keywords
Variants Tagging LGALS-3 Haplotype Block in Association with First Myocardial Infarction and Plasma Galectin-3 Six Months after the Acute Event
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DOI: 10.3390/genes14010109
Abstract: Galectin-3 is encoded by LGALS-3, located in a unique haplotype block in Caucasians. According to the Tagger server, rs4040064, rs11628437, and rs7159490 cover 82% (r2 > 0.8) of the genetic variance of this HapBlock. Our… read more here.
Keywords: myocardial infarction; plasma galectin; first myocardial; galectin ... See more keywords