PXR haplotype clusters will affect the pharmacokinetics of ciclosporin in Chinese renal transplant recipients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13206
Abstract: PXR was reported to be the key nuclear receptor regulating the expression of metabolizing enzymes and transporters. The aim of this study was to evaluate the influence of PXR haplotype clusters on ciclosporin concentration in… read more here.
Keywords: pxr haplotype; haplotype clusters; renal transplant; transplant recipients ... See more keywords
imputeqc: an R package for assessing imputation quality of genotypes and optimizing imputation parameters
Sign Up to like & getrecommendations! Published in 2020 at "BMC Bioinformatics"
DOI: 10.1186/s12859-020-03589-0
Abstract: The imputation of genotypes increases the power of genome-wide association studies. However, the imputation quality should be assessed in each particular case. Nevertheless, not all imputation softwares control the error of output, e.g., the last… read more here.
Keywords: imputation quality; imputeqc package; imputation; haplotype clusters ... See more keywords