Kinetic inequivalence between α and β subunits of ligand dissociation from ferrous nitrosylated human haptoglobin:hemoglobin complexes. A comparison with O2 and CO dissociation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111272
Abstract: Haptoglobin (Hp) counterbalances the adverse effects of extra-erythrocytic hemoglobin (Hb) by trapping the αβ dimers of Hb in the bloodstream. In turn, the Hp:Hb complexes display Hb-like reactivity. Here, the kinetics of NO dissociation from… read more here.
Keywords: dissociation ferrous; hemoglobin; dissociation; ferrous nitrosylated ... See more keywords
A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2002483117
Abstract: Significance Haptoglobin (Hp) is one of the most abundant plasma proteins; it binds with high affinity to hemoglobin (Hb). Thereby Hp protects against the toxic effects of the heme when Hb leaks into plasma from… read more here.
Keywords: specific proteoforms; genotype; haptoglobin; wealth genotype ... See more keywords
Re-evaluation of the measurement of haptoglobin in human plasma samples
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2122077
Abstract: Abstract Haptoglobin (Hp) is an abundant plasma protein scavenging hemoglobin (Hb) via CD163 on macrophages. This process consumes Hp, which therefore negatively correlates to hemolysis. However, exact measurements of Hp plasma levels are complicated by… read more here.
Keywords: human plasma; measurement haptoglobin; haptoglobin; plasma ... See more keywords
Haptoglobin and the related haptoglobin protein: the N-terminus makes the difference
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1837675
Abstract: Abstract Haptoglobin related protein (Hpr) is a component of the trypanosome lytic factor (TLF), a complex acting in the innate immune response against African trypanosomes. Like haptoglobin (Hp), Hpr binds hemoglobin (Hb) in the blood,… read more here.
Keywords: related haptoglobin; hpr hpr; haptoglobin; hpr ... See more keywords
Urine Haptoglobin and Haptoglobin-Related Protein Predict Response to Spironolactone in Patients With Resistant Hypertension
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DOI: 10.1161/hypertensionaha.118.12242
Abstract: Resistant hypertension prevalence is progressively increasing, and prolonged exposure to suboptimal blood pressure control results in higher cardiovascular risk and end-organ damage. Among various antihypertensive agents, spironolactone seems the most effective choice to treat resistant… read more here.
Keywords: response spironolactone; haptoglobin; resistant hypertension; hypertension ... See more keywords
Abstract WMP97: Haptoglobin is Associated With Increased Early Perihematoma Edema Progression in Spontaneous Intracranial Hemorrhage
Sign Up to like & getrecommendations! Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.wmp97
Abstract: Introduction: Perihematomal edema in intracranial hemorrhage (ICH) is influenced by free hemoglobin clearance and inflammation. Serum Haptoglobin (Hp) binds free hemoglobin, affecting clearance as well as free radical production, resulting in inflammation. Of the three… read more here.
Keywords: intracranial hemorrhage; haptoglobin; rate; edema ... See more keywords
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus
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DOI: 10.1177/2047487318776829
Abstract: Introduction and background Haptoglobin (Hp) is considered to be an antioxidant and protective against cardiovascular complications. Polymorphisms in the Hp gene interact with diabetes mellitus to affect the risk of vascular complications. Methods We review… read more here.
Keywords: protean role; haptoglobin; type diabetes; diabetes mellitus ... See more keywords
Low Level of Haptoglobin in Lupus
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DOI: 10.1177/2324709616689106
Abstract: Haptoglobin levels are measured in systematic lupus erythematosus patients as part of the workup for anemia, with low levels indicating hemolysis. Haptoglobin is an acute phase protein. We present 2 lupus patients who were found… read more here.
Keywords: medicine; level haptoglobin; haptoglobin; haptoglobin lupus ... See more keywords
The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO
Sign Up to like & getrecommendations! Published in 2022 at "Critical Care"
DOI: 10.1186/s13054-022-03894-5
Abstract: Background Increased plasma concentrations of circulating cell-free hemoglobin (CFH) are supposed to contribute to the multifactorial etiology of acute kidney injury (AKI) in critically ill patients while the CFH-scavenger haptoglobin might play a protective role.… read more here.
Keywords: cell free; cfh; haptoglobin; aki ... See more keywords
DEVELOPMENT OF A QUANTITATIVE IMMUNOASSAY FOR SERUM HAPTOGLOBIN AS A PUTATIVE DISEASE MARKER IN THE SOUTHERN WHITE RHINOCEROS (CERATOTHERIUM SIMUM SIMUM)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Zoo and Wildlife Medicine"
DOI: 10.1638/2020-0010
Abstract: Abstract: Objective disease markers in the southern white rhinoceros (Ceratotherium simum simum) are in high demand. In the field, such markers are typically needed to decide whether a captured white rhinoceros is fit to cope… read more here.
Keywords: southern white; disease; serum; haptoglobin ... See more keywords
Progress on haptoglobin and metabolic diseases
Sign Up to like & getrecommendations! Published in 2021 at "World Journal of Diabetes"
DOI: 10.4239/wjd.v12.i3.206
Abstract: Haptoglobin (Hp) is an acidic glycoprotein, existing in the serum and other body fluids of human beings and a variety of mammals. Hp is produced in the liver, white adipose tissue, and the kidney. The… read more here.
Keywords: progress haptoglobin; haptoglobin metabolic; metabolic diseases; haptoglobin ... See more keywords