Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations
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DOI: 10.1038/s41388-020-01528-0
Abstract: Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population. However, the inter-patient and intra-tumor heterogeneity has not been addressed at single-cell resolution. Here we performed single-cell RNA sequencing (scRNA-seq) of total 125,674 cells from… read more here.
Keywords: single cell; tumor; egfr mutations; harboring egfr ... See more keywords
First‐line immune checkpoint therapy in metastatic squamous cell lung cancer harboring both EGFR mutation and high expression of PD‐L1: A case report
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DOI: 10.1111/1759-7714.13436
Abstract: A 90‐year‐old female was admitted to our hospital with a history of a dry cough. Chest computed tomography (CT) scan showed a tumor shadow, and CT‐guided lung biopsy revealed squamous cell carcinoma harboring an EGFR… read more here.
Keywords: harboring egfr; squamous cell; egfr mutation; lung ... See more keywords
Treatment of Leptomeningeal Metastases in a Patient with Non-Small Cell Lung Cancer Harboring EGFR T790M Mutation
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DOI: 10.1159/000480452
Abstract: Background: Leptomeningeal metastasis (LM) is an uncommon complication in patients with solid tumors, associated with poor survival. However, LM appears to be more frequent in lung cancer patients with EGFR mutations, posing a unique clinical… read more here.
Keywords: egfr t790m; lung cancer; t790m mutation; harboring egfr ... See more keywords
Comparison of the efficacies of first-generation epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in patients with advanced non-small-cell lung cancer harboring EGFR mutations
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DOI: 10.1186/s12885-018-4911-7
Abstract: BackgroundCompared with standard chemotherapy, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are more effective in patients with advanced non-small-cell lung cancer (NSCLC) harboring EGFR mutations. However, data comparing the efficacies of different EGFR−TKIs, especially… read more here.
Keywords: egfr mutations; brain metastasis; harboring egfr; cancer ... See more keywords
Antitumor activity of osimertinib in NSCLC harboring EGFR exon 20 insertions.
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DOI: 10.1200/jco.2017.35.15_suppl.9030
Abstract: 9030Background: EGFR exon 20 insertions (Ex20Ins), the 3rd most common EGFR activating mutation, are generally unresponsive to 1st and 2nd generation EGFR-TKIs. Development of EGFR-TKIs that effectively target NSCLC with Ex20Ins mutations represents a major… read more here.
Keywords: egfr; egfr exon; harboring egfr; exon insertions ... See more keywords