Polymer‐ and Lipid‐Based Nanostructures Serving Wound Healing Applications: A Review
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202402699
Abstract: Management of hard‐to‐heal wounds often requires specialized care that surpasses the capabilities of conventional treatments. Even the most advanced commercial products lack the functionality to meet the needs of hard‐to‐heal wounds, especially those complicated by… read more here.
Keywords: heal wounds; polymer lipid; wound healing; lipid based ... See more keywords
A regenerative approach to the pharmacological management of hard-to-heal wounds.
Sign Up to like & getrecommendations! Published in 2022 at "Biochimie"
DOI: 10.1016/j.biochi.2021.12.016
Abstract: A wound is considered hard-to-heal when, despite the appropriate clinical analysis and intervention, the wound area reduces by less than a third at four weeks and complete healing fails to occur within 12 weeks. The… read more here.
Keywords: pharmacological management; hard heal; approach pharmacological; heal wounds ... See more keywords
Candidate Biomarkers for Hard‐to‐Heal Wounds Revealed by Single‐Cell RNA Sequencing of Wound Fluid in Murine Wound Models
Sign Up to like & getrecommendations! Published in 2025 at "Wound Repair and Regeneration"
DOI: 10.1111/wrr.70038
Abstract: Wound healing is often hindered by hyperglycemia, chronic inflammation and ageing. Despite extensive research on the pathophysiology of hard‐to‐heal wounds, wound healing remains complex and poses challenges in treatment and management. Current wound treatments and… read more here.
Keywords: heal wounds; wound models; wound fluid; wound ... See more keywords
Direct metagenomics investigation of non-surgical hard-to-heal wounds: a review
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Clinical Microbiology and Antimicrobials"
DOI: 10.1186/s12941-024-00698-z
Abstract: Non-surgical chronic wounds, including diabetes-related foot diseases (DRFD), pressure injuries (PIs) and venous leg ulcers (VLU), are common hard-to-heal wounds. Wound evolution partly depends on microbial colonisation or infection, which is often confused by clinicians,… read more here.
Keywords: heal wounds; non surgical; microbiology; investigation ... See more keywords
Quality of life of patients with hard-to-heal leg ulcers: a review of nursing documentation.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of community nursing"
DOI: 10.12968/bjcn.2020.25.sup12.s12
Abstract: People with hard-to-heal leg ulcers experience reduced quality of life (QoL), including physical, mental and social aspects; this, in turn, negatively affects the wound healing process. QoL is often overlooked by health professionals treating those… read more here.
Keywords: quality life; documentation; patients hard; heal leg ... See more keywords
Benefits of negative pressure wound therapy with instillation in the treatment of hard-to-heal wounds: a case series.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of wound care"
DOI: 10.12968/jowc.2020.29.4.248
Abstract: OBJECTIVE Impaired wound healing can lead to hard-to-heal wounds, which impact on patients, clinicians and healthcare systems. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) was developed to manage wounds through early-stage cleansing.… read more here.
Keywords: heal wounds; hard heal; negative pressure; wound ... See more keywords
Treatment of hard-to-heal leg ulcers with hyaluronic acid, sodium alginate and negative pressure wound therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of wound care"
DOI: 10.12968/jowc.2020.29.7.419
Abstract: OBJECTIVE Hard-to-heal lower extremity ulcer is a common healthcare problem and can lead to a poor quality of life (QoL). Despite the advances in wound care, conventional therapies, such as necrotic tissue debridement, cleansing, treatment… read more here.
Keywords: hard heal; heal leg; treatment; group ... See more keywords
Manejo de heridas traumáticas de difícil cicatrización con colgajos microvasculares.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of wound care"
DOI: 10.12968/jowc.2020.29.latam_sup_2.27
Abstract: OBJECTIVE Present different flap alternatives when performing microvascular free-flap reconstruction in acute hard-to-heal wounds. METHOD A retrospective review of patients whose acute hard-to-heal wounds were treated with microvascular free-flap reconstruction. Data on demographics, wound aetiology,… read more here.
Keywords: flap; free flap; hard heal; flap reconstruction ... See more keywords
Treating hard-to-heal ulcers: biocellulose with nanosilver compared with silver sulfadiazine.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of wound care"
DOI: 10.12968/jowc.2020.29.sup12.s33
Abstract: OBJECTIVE Controlling infection and promoting healing should be the aims of hard-to-heal diabetic ulcer treatment, along with improving a patient's general condition and their blood sugar control. Many hard-to-heal diabetic ulcers present with cavities, tracks… read more here.
Keywords: silver sulfadiazine; treatment; heal diabetic; hard heal ... See more keywords
Implantation of cryopreserved umbilical cord allograft in hard-to-heal foot wounds: a retrospective study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of wound care"
DOI: 10.12968/jowc.2020.29.sup8.s12
Abstract: OBJECTIVE The objective of this study was to assess the clinical effectiveness of surgically implanted cryopreserved human umbilical cord allograft in treating hard-to-heal wounds with and without osteomyelitis. METHOD In this single-centre, retrospective investigation, wounds… read more here.
Keywords: cord allograft; umbilical cord; implantation cryopreserved; cryopreserved umbilical ... See more keywords
Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of wound care"
DOI: 10.12968/jowc.2021.30.1.26
Abstract: OBJECTIVE We evaluated the effects of a specialised oral nutritional supplement (ONS) containing arginine and proline, with high vitamin A, C and E, zinc and selenium content, on the repair of hard-to-heal wounds. METHOD Patients… read more here.
Keywords: hard heal; specialised ons; heal wounds; proline ... See more keywords