Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond
Sign Up to like & getrecommendations! Published in 2024 at "Parasitology"
DOI: 10.1017/s0031182024001124
Abstract: Human alveolar echinococcosis is a hard-to-treat and largely untreated parasitic disease with high associated health care costs. The current antiparasitic treatment for alveolar echinococcosis relies exclusively on albendazole, which does not act parasiticidally and can… read more here.
Keywords: hard treat; echinococcosis; alveolar echinococcosis; drug ... See more keywords
Minimal Functionalization of Ruthenium Compounds with Enhanced Photoreactivity against Hard-to-Treat Cancer Cells and Resistant Bacteria
Sign Up to like & getrecommendations! Published in 2024 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.4c02235
Abstract: Metallocompounds have emerged as promising new anticancer agents, which can also exhibit properties to be used in photodynamic therapy. Here, we prepared two ruthenium-based compounds with a 2,2′-bipyridine ligand conjugated to an anthracenyl moiety. These… read more here.
Keywords: hard treat; minimal functionalization; cancer; ruthenium ... See more keywords
Urinary infections are complex and hard to treat
Sign Up to like & getrecommendations! Published in 2017 at "British Medical Journal"
DOI: 10.1136/bmj.j5766
Abstract: Kronenberg and colleagues find that a quinolone beats a non-steroidal anti-inflammatory drug at treating dipstick positive urinary tract infections (UTIs).1 Why are we testing this? We have vastly more serious problems. Culture of 103-106 colony… read more here.
Keywords: complex hard; hard treat; urinary infections; infections complex ... See more keywords
Derived from a Platform of Innovative Therapeutic Molecular Clusters (TMC), Ag5 Is a Highly Potent and Differentiated Molecule That Promises to be Efficacious in Hard-to-Treat Hematological Cancers
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-136618
Abstract: [Background on medical need in hematology]Even though significant progress has been made in a number of hematological malignancies in recent years, an unmet medical need still remains in indications such as multiple myeloma (MM), chronic… read more here.
Keywords: therapeutic molecular; ag5; treat hematological; hard treat ... See more keywords
Fabric Retrofit of a Hard-to-Treat, Pre-1919 House in Preparation for Heat Pump Use
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DOI: 10.3390/en17194939
Abstract: The uptake of low-carbon domestic heating systems is a significant strategy towards global targets of reducing greenhouse emissions and mitigating climate change. Pre-1900 hard-to-treat houses will still be existing in the next 25 years, and… read more here.
Keywords: hard treat; heat pump; house;
Hard-to-Treat Areas in Psoriasis: An Underevaluated Part of the Disease
Sign Up to like & getrecommendations! Published in 2025 at "Life"
DOI: 10.3390/life15030425
Abstract: Hard-to-treat areas in psoriasis vulgaris, i.e., the scalp, nails, genital area, palms, and soles, are less commonly diagnosed and treated. Our understanding of the complex etiopathogenesis and treatment of psoriasis vulgaris has advanced considerably in… read more here.
Keywords: hard treat; treat areas; areas psoriasis; life ... See more keywords