Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.04.019
Abstract: l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT). AGAT also catalyzes the formation of guanidinoacetate (GAA) from Arg and glycine (Gly). GAA is converted to creatine (N-methyl guanidinoacetate) by… read more here.
Keywords: evidence lysine; arginase; harg; homoarginine ... See more keywords
Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4 weeks
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DOI: 10.1016/j.jocn.2018.01.035
Abstract: l-homoarginine (l-hArg) is an endogenous non-proteinogenic amino acid. Low l-hArg concentrations are associated with increased all-cause mortality, fatal strokes, and worse outcome after stroke. On the other hand, oral supplementation with l-hArg in mice improved… read more here.
Keywords: supplementation; cognitive performance; healthy humans; harg ... See more keywords
Markers of nitric oxide are associated with sepsis severity: an observational study
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DOI: 10.1186/s13054-017-1782-2
Abstract: BackgroundNitric oxide (NO) regulates processes involved in sepsis progression, including vascular function and pathogen defense. Direct NO measurement in patients is unfeasible because of its short half-life. Surrogate markers for NO bioavailability are substrates of… read more here.
Keywords: sepsis; study; harg; sepsis severity ... See more keywords
Homoarginine—A prognostic indicator in adolescents and adults with complex congenital heart disease?
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DOI: 10.1371/journal.pone.0184333
Abstract: Background Homoarginine (hArg) has been shown to be of prognostic value in patients with chronic left heart failure. The present study aims to assess the clinical utility and prognostic value of hArg levels in patients… read more here.
Keywords: heart; complex congenital; heart failure; harg ... See more keywords
Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094734
Abstract: L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys ↔ hArg + Orn; equilibrium constant KhArg. AGAT also catalyzes the formation of guanidinoacetate… read more here.
Keywords: amino acids; time; isoprenaline; heart ... See more keywords
Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810649
Abstract: The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO3; n = 8) or placebo (NaCl; n = 9) (each 0.1 mmol/kg body weight/d for 9 days)… read more here.
Keywords: supplementation; plasma concentrations; sodium; synthesis ... See more keywords