Harmaline isolated from Peganum harmala suppresses growth of esophageal squamous cell carcinoma through targeting mTOR
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DOI: 10.1002/ptr.7289
Abstract: Harmaline is a naturally occurring β‐carboline alkaloid that is isolated from Peganum harmala. It has shown efficacy in treating Parkinson's disease and has been reported to exhibit antimicrobial and anticancer properties. However, the molecular mechanism… read more here.
Keywords: cell; harmaline; mtor; growth ... See more keywords
Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5′-Chloro-5′-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor
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DOI: 10.1016/j.neuroscience.2019.12.045
Abstract: The primary cause of harmaline tremor, which is a model of essential tremor (ET) in animals, is excessive activation of olivocerebellar glutamatergic climbing fibers. Our recent study indicated that 5'-chloro-5'-deoxy-(±)-ENBA (5'Cl5'd-(±)-ENBA), a potent and selective… read more here.
Keywords: harmaline induced; adenosine receptor; harmaline; model ... See more keywords
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine.
Sign Up to like & getrecommendations! Published in 2022 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(22)60151-1
Abstract: Harmaline and harmine are β-carboline alkaloids with effective pharmacological effects. Harmaline can be transformed into harmine after oral administration. However, enzymes involved in the metabolic pathway remain unclear. In this study, harmaline was incubated with… read more here.
Keywords: blood; dehydrogenation; harmaline harmine; harmine ... See more keywords
Discovery of Harmaline as a Potent Inhibitor of Sphingosine Kinase-1: A Chemopreventive Role in Lung Cancer
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DOI: 10.1021/acsomega.0c02165
Abstract: The sphingosine kinase-1/sphingosine-1-phosphate pathway is linked with the cancer progression and survival of the chemotherapy-challenged cells. Sphingosine kinase-1 (SphK1) has emerged as an attractive drug target, but their inhibitors from natural sources are limited. In… read more here.
Keywords: kinase; lung cancer; sphingosine kinase; harmaline ... See more keywords