Interspecies metabolic diversity of harmaline and harmine in in vitro 11 mammalian liver microsomes.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2028
Abstract: The β-carboline alkaloids harmaline and harmine are widely present in hallucinogenic plants with great potential for treating depression, Parkinson's disease, and Alzheimer's disease. The present study was to elucidate metabolic difference of harmaline and harmine… read more here.
Keywords: mammalian liver; harmaline harmine; liver microsomes; harmine ... See more keywords
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine.
Sign Up to like & getrecommendations! Published in 2022 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(22)60151-1
Abstract: Harmaline and harmine are β-carboline alkaloids with effective pharmacological effects. Harmaline can be transformed into harmine after oral administration. However, enzymes involved in the metabolic pathway remain unclear. In this study, harmaline was incubated with… read more here.
Keywords: blood; dehydrogenation; harmaline harmine; harmine ... See more keywords