Interspecies metabolic diversity of harmaline and harmine in in vitro 11 mammalian liver microsomes.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2028
Abstract: The β-carboline alkaloids harmaline and harmine are widely present in hallucinogenic plants with great potential for treating depression, Parkinson's disease, and Alzheimer's disease. The present study was to elucidate metabolic difference of harmaline and harmine… read more here.
Keywords: mammalian liver; harmaline harmine; liver microsomes; harmine ... See more keywords
Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF‐&kgr;B pathway
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.04.050
Abstract: ABSTRACT Enterovirus 71 (EV71) infection of young children can cause neurological manifestations, which is mainly responsible for the fatality. Although a vaccine is recently available for preventing enterovirus 71 infection, its efficacy remains to be… read more here.
Keywords: ev71 infection; replication; ev71 replication; harmine ... See more keywords
Harmine induced apoptosis in Spodoptera frugiperda Sf9 cells by activating the endogenous apoptotic pathways and inhibiting DNA topoisomerase I activity.
Sign Up to like & getrecommendations! Published in 2019 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2019.01.002
Abstract: Harmine, a useful botanical compound, has demonstrated insecticidal activity against some pests. However, harmine's mechanism of action has not been thoroughly elucidated to date. To preliminarily explore harmine's insecticidal mechanisms, the cytotoxicity of harmine against… read more here.
Keywords: sf9 cells; induced apoptosis; harmine; harmine induced ... See more keywords
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine.
Sign Up to like & getrecommendations! Published in 2022 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(22)60151-1
Abstract: Harmaline and harmine are β-carboline alkaloids with effective pharmacological effects. Harmaline can be transformed into harmine after oral administration. However, enzymes involved in the metabolic pathway remain unclear. In this study, harmaline was incubated with… read more here.
Keywords: blood; dehydrogenation; harmaline harmine; harmine ... See more keywords
Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Psychoactive Drugs"
DOI: 10.1080/02791072.2016.1260189
Abstract: ABSTRACT Harmine is a natural β-carboline alkaloid found in several botanical species, such as the Banisteriopsis caapi vine used in the preparation of the hallucinogenic beverage ayahuasca and the seeds of Syrian rue (Peganum harmala).… read more here.
Keywords: preclinical studies; harmine; natural carboline; carboline alkaloid ... See more keywords
Combination of doxorubicin with harmine-loaded liposomes exerting synergistic antitumor efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2017.1405432
Abstract: Abstract Context: Long-circulation (PEGLip), pH-sensitive (PEOzLip), and active targeted liposomes (PEG-TATLip)-loading doxorubicin (DOX) and harmine (HM) were prepared. Their physicochemical properties and antitumor effect were investigated. Objectives: The aims of the present study were to… read more here.
Keywords: synergistic antitumor; antitumor efficacy; loaded liposomes; harmine ... See more keywords
The transdermal performance, pharmacokinetics, and anti-inflammatory pharmacodynamics evaluation of harmine-loaded ethosomes
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2019.1706549
Abstract: Abstract Harmine (HAR) is a β-carboline alkaloid with anti-inflammatory and antipruritic effect. However, the low bioavailability and side effects of HAR severely limited its clinical application. The main objective of this study was to develop… read more here.
Keywords: anti inflammatory; loaded ethosomes; transdermal performance; hle ... See more keywords
Enhanced Glioblastoma Selectivity of Harmine via the Albumin Carrier.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3321
Abstract: Glioblastoma, the most common tumor in the brain, has witnessed very little clinical progress over the last decades. Exploring and discovering new therapeutic strategies for glioblastoma has become a critical problem. Harmine (HM), belonging to… read more here.
Keywords: glioblastoma selectivity; selectivity harmine; enhanced glioblastoma; selectivity ... See more keywords
Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA
Sign Up to like & getrecommendations! Published in 2020 at "Biology Open"
DOI: 10.1242/bio.052969
Abstract: ABSTRACT Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as… read more here.
Keywords: latency; harmine; latency reversing; hiv latency ... See more keywords
Loading Harmine On Nanographene Changes The Inhibitory Effects of Free Harmine Against MCF7 and Fibroblast Cells
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.21203/rs.3.rs-171554/v1
Abstract: Today cancer is one of the main causes of death all over the world. Chemotherapy, which is one of the main therapies in the treatment of cancer, causes several side effects by damaging healthy cells.… read more here.
Keywords: fibroblast cells; free harmine; harmine; cell loss ... See more keywords
Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s205097
Abstract: Purpose Pancreatic carcinoma is one of the most deadliest types of cancer, and relatively insensitive to the currently available chemotherapy. Thus, the discovery of novel therapeutic agents to prolong the survival times of patients with… read more here.
Keywords: cancer cells; treatment; harmine; cancer ... See more keywords