Harnessing protein folding neural networks for peptide–protein docking
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27838-9
Abstract: Highly accurate protein structure predictions by deep neural networks such as AlphaFold2 and RoseTTAFold have tremendous impact on structural biology and beyond. Here, we show that, although these deep learning approaches have originally been developed… read more here.
Keywords: protein folding; neural networks; peptide protein; folding neural ... See more keywords
Harnessing Protein Corona for Biomimetic Nanomedicine Design
Sign Up to like & getrecommendations! Published in 2022 at "Biomimetics"
DOI: 10.3390/biomimetics7030126
Abstract: Nanoparticles (NPs) are usually treated as multifunctional agents combining several therapeutical applications, like imaging and targeting delivery. However, clinical translation is still largely hindered by several factors, and the rapidly formed protein corona on the… read more here.
Keywords: corona biomimetic; harnessing protein; nanomedicine design; protein corona ... See more keywords
Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154718
Abstract: Necroptosis has emerged as an exciting target in oncological, inflammatory, neurodegenerative, and autoimmune diseases, in addition to acute ischemic injuries. It is known to play a role in innate immune response, as well as in… read more here.
Keywords: machine learning; ripk1 inhibitors; harnessing protein; new scaffolds ... See more keywords