Solvent-free Buchwald–Hartwig amination with low palladium loadings
Sign Up to like & getrecommendations! Published in 2017 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2017.11.027
Abstract: A highly efficient ‘green’ solvent-free monoarylation of primary anilines with aryl bromides mediated by the expanded-ring N-heterocyclic carbene palladium complex (THP-Dipp)Pd(cinn)Cl [THP-Dipp is 1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene; cinn is cinnamyl] can be performed at low catalyst loadings (0.1… read more here.
Keywords: amination low; hartwig amination; buchwald hartwig; free buchwald ... See more keywords
Synthesis of N-heterocyclic carbene-Pd(II) complexes and their catalytic activity in the Buchwald-Hartwig amination of aryl chlorides
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.11.026
Abstract: Abstract Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary… read more here.
Keywords: hartwig amination; buchwald hartwig; catalytic activity; aryl chlorides ... See more keywords
Buchwald–Hartwig Amination, High-Throughput Experimentation, and Process Chemistry: An Introduction via Undergraduate Laboratory Experimentation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemical Education"
DOI: 10.1021/acs.jchemed.0c01355
Abstract: This three-part laboratory experiment investigates key aspects of the Buchwald–Hartwig amination cross-coupling reaction through guided-inquiry learning strategies. The first part of this experimen... read more here.
Keywords: buchwald hartwig; laboratory; experimentation; hartwig amination ... See more keywords
Rapid Evaluation of the Mechanism of Buchwald-Hartwig Amination and Aldol Reactions Using Intramolecular 13C Kinetic Isotope Effects.
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DOI: 10.1021/acscatal.0c04752
Abstract: A practical approach is introduced for the rapid determination of 13C kinetic isotope effects that utilizes a "designed" reactant with two identical reaction sites. The mechanism of the Buchwald-Hartwig amination of tert-butylbromobenzene with primary and… read more here.
Keywords: 13c kinetic; hartwig amination; methodology; mechanism ... See more keywords
Lithium sensors based on photophysical changes of 1-aza-12-crown-4 naphthalene derivatives synthesized via Buchwald–Hartwig amination
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05746h
Abstract: Lithium detection is of great significance in many applications. Lithium-sensing compounds with high selectivity are scarce and, if any, complicated to synthesize. We herein report a novel yet simple compound that can detect lithium ions… read more here.
Keywords: synthesized via; aza crown; buchwald hartwig; hartwig amination ... See more keywords