Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14070
Abstract: Hyaluronic acid synthase 2 (HAS2) is suggested to play a critical role in malignancy and is abnormally expressed in many carcinomas. However, its role in colorectal cancer (CRC) malignancy and specific signaling mechanisms remain obscure.… read more here.
Keywords: has2; colorectal cancer; acid synthase; hyaluronic acid ... See more keywords
The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-β Signaling and Upregulating HAS2
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00107-22
Abstract: HAS2 antisense RNA 1 (HAS2-AS1) is a long noncoding RNA that has increased expression in mature granulosa cells (GCs) and contributes to cumulus expansion by regulating HAS2 expression. However, the roles of HAS2-AS1 during the… read more here.
Keywords: has2; has2 as1; expression; tgf signaling ... See more keywords
Abstract Wed057: Impact of Fibroblast-Derived Hyaluronan on Acute Ventricular Remodeling
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.wed057
Abstract: Background: Following myocardial infarction (MI), the extracellular matrix (ECM) component hyaluronan (HA) accumulates. Our recent work shows that Has2 expression in fibroblasts drives accumulation of HA. The role of HA following MI is largely unknown.… read more here.
Keywords: per group; acute ventricular; group; fibroblast derived ... See more keywords
HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-019-0495-3
Abstract: BackgroundThe cumulus expansion process is one of the LH mediated ovulatory processes. Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process. Recently, the lncRNA HAS2 antisense… read more here.
Keywords: has2; has2 expression; has2 as1; role ... See more keywords
Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.770305
Abstract: HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma. However,… read more here.
Keywords: has2; insensitivity; mice; airway remodeling ... See more keywords