ROS scavenger TEMPOL mitigates TNF alpha induced ER stress in hASM cells
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DOI: 10.1152/physiol.2023.38.s1.5725740
Abstract: The impact of airway inflammation is mediated by pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα), which underlies several respiratory diseases, including COVID-19, asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). In human… read more here.
Keywords: ros scavenger; hasm; stress response; physiology ... See more keywords
Chemical chaperone 4-PBA mitigates TNF alpha mediated ER stress in hASM cells
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DOI: 10.1152/physiol.2023.38.s1.5726129
Abstract: Airway inflammation and pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα) underlie the pathophysiology of respiratory diseases, including asthma. Previously, we showed that TNFα selectively activates the inositol-requiring enzyme 1α (IRE1α)/X-box binding protein 1… read more here.
Keywords: pba mitigates; hasm cells; physiology; mitigates tnf ... See more keywords
Succinate dehydrogenase inhibition decreases mitochondrial respiratory capacity in human airway smooth muscle cells
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DOI: 10.1152/physiol.2023.38.s1.5727552
Abstract: Succinate dehydrogenase (SDH) is a mitochondrial enzyme that participates in both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) as Complex II. In the TCA cycle, SDH catalyzes the oxidation of succinate… read more here.
Keywords: sdh; hasm cells; physiology; respiratory capacity ... See more keywords