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   Articles with "haspin" as a keyword



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Slowly on, Slowly off: Bisubstrate‐Analogue Conjugates of 5‐Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201600697

Abstract: The atypical protein kinase haspin is a key player in mitosis by catalysing the phosphorylation of Thr3 in histone H3, and thus ensuring the normal function of the chromosomal passenger complex. Here, we report the development… read more here.

Keywords: kinase haspin; kinase; bisubstrate analogue; protein kinase ... See more keywords

3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties.

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recommendations! Published in 2018 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2018.03.031

Abstract: Histone modification, a post-translational modification of histones and involving various covalent tags, such as methyl, phosphate and acetate groups, affects gene expression and hence modulates various cellular events, including growth and proliferation. Consequently histone-modifying proteins… read more here.

Keywords: kinase inhibitors; pyrazolo quinoline; quinoline haspin; haspin ... See more keywords
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Roles and regulation of Haspin kinase and its impact on carcinogenesis.

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recommendations! Published in 2022 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2022.110303

Abstract: Cancer therapy is based on the selective clearance of malignant cells without severely damaging healthy tissues, and current clinical practice is constantly in need for new therapeutic targets in tumor management. The atypical protein kinase… read more here.

Keywords: haspin; roles regulation; carcinogenesis; kinase ... See more keywords
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Haspin knockdown can inhibit progression and development of pancreatic cancer in vitro and vivo.

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recommendations! Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2019.111605

Abstract: BACKGROUND Pancreatic cancer is one of the most aggressive and lethal malignancies and it is the eighth most common cause of death from cancer worldwide. The purpose of this study was to investigate the role… read more here.

Keywords: haspin; pancreatic cancer; expression; cancer ... See more keywords
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Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase

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recommendations! Published in 2017 at "Cell Discovery"

DOI: 10.1038/celldisc.2016.49

Abstract: Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed in a range of solid tumors, which is linked with tumor progression and poor… read more here.

Keywords: spindle; checkpoint; haspin; late phase ... See more keywords
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A kinase‐dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion

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recommendations! Published in 2018 at "EMBO reports"

DOI: 10.15252/embr.201744737

Abstract: Sister‐chromatid cohesion mediated by the cohesin complex is fundamental for precise chromosome segregation in mitosis. Through binding the cohesin subunit Pds5, Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin… read more here.

Keywords: cohesin; centromere cohesion; cohesion; kinase dependent ... See more keywords

Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer’s Disease

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recommendations! Published in 2023 at "Biology"

DOI: 10.3390/biology12020320

Abstract: Simple Summary HASPIN plays important roles in chromosome segregation during cell division by phosphorylating histone H3 at threonine. We showed that HASPIN was expressed in the hippocampus and phosphorylated the tau protein, acting as a… read more here.

Keywords: tau protein; alzheimer disease; haspin; soybean sprouts ... See more keywords
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Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22147753

Abstract: Primary cilia are commonly found on most quiescent, terminally differentiated cells and play a major role in the regulation of the cell cycle, cell motility, sensing, and cell–cell communication. Alterations in ciliogenesis and cilia maintenance… read more here.

Keywords: phosphorylation thr3; primary cilia; haspin; cell ... See more keywords
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Analysis of Ser/Thr Kinase HASPIN-Interacting Proteins in the Spermatids

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23169060

Abstract: HASPIN is predominantly expressed in spermatids, and plays an important role in cell division in somatic and meiotic cells through histone H3 phosphorylation. The literature published to date has suggested that HASPIN may play multiple… read more here.

Keywords: ser thr; haspin; thr kinase; haspin interacting ... See more keywords

Halogen Bonding in Haspin-Halogenated Tubercidin Complexes: Molecular Dynamics and Quantum Chemical Calculations

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27030706

Abstract: Haspin, an atypical serine/threonine protein kinase, is a potential target for cancer therapy. 5-iodotubercidin (5-iTU), an adenosine derivative, has been identified as a potent Haspin inhibitor in vitro. In this paper, quantum chemical calculations and… read more here.

Keywords: chemical calculations; haspin; halogenated tubercidin; halogen bonding ... See more keywords