microRNA‐486‐5p is implicated in the cisplatin‐induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23039
Abstract: The proinflammatory property of cisplatin is potentially destructive and contributes to the pathogenesis of acute kidney injury (AKI). The role and upstream regulatory mechanism of histone acetyltransferase 1 (HAT1) in acute kidney inflammation are still… read more here.
Keywords: inflammation; cisplatin induced; hat1; tubular epithelial ... See more keywords
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.05.034
Abstract: The energetic costs of duplicating chromatin are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs. By studying chromatin modifiers regulated by epithelial growth factor, we identified histone acetyltransferase 1 (HAT1) as… read more here.
Keywords: acetylation; production acetylation; histone production; hat1 ... See more keywords
Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00843
Abstract: Lysine acetylation has emerged as one of the most important post-translational modifications, regulating different biological processes. However, its regulation by lysine acetyltransferases is still unclear in most cases. Hat1 is a lysine acetyltransferase originally identified… read more here.
Keywords: acetylation; hat1 hat1; hat1; hat1 dependent ... See more keywords
Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)
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DOI: 10.1111/acel.12992
Abstract: Histone acetyltransferase 1 (Hat1) is responsible for the acetylation of newly synthesized histone H4 on lysines 5 and 12 during the process of chromatin assembly. To understand the broader biological role of Hat1, we have… read more here.
Keywords: early onset; hat1; acetyltransferase hat1; onset aging ... See more keywords