Efficacy of ruxolitinib for HAVCR2 mutation-associated hemophagocytic lymphohistiocytosis and panniculitis manifestations in children.
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DOI: 10.1111/bjh.18817
Abstract: Frequent germline mutations of HAVCR2, recently identified in subcutaneous panniculitis-like T-cell lymphoma (SPTCL), are associated with an increased risk of hemophagocytic lymphohistiocytosis (HLH). However, SPTCL-HLH represents a challenge because of the difficulties in treatment with… read more here.
Keywords: hlh; havcr2; efficacy ruxolitinib; hemophagocytic lymphohistiocytosis ... See more keywords
Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines
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DOI: 10.4155/fsoa-2017-0121
Abstract: Aim: Variants of TIM-3/HAVCR2 3′UTR miRNA binding sites are significantly associated with cancer; however, roles in post-transcriptional regulation have not been elucidated. Methods: The regulatory and coding region single nucleotide polymorphisms (SNPs) of TIM-3/HAVCR2 were… read more here.
Keywords: havcr2; variants tim; havcr2 utr; mirna binding ... See more keywords