Human beta-defensins 2 and 4 are dysregulated in patients with coronavirus disease 19
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Pathogenesis"
DOI: 10.1016/j.micpath.2021.105205
Abstract: Antimicrobial peptides (AMPs) have recently been proposed as significant immunological factors involved in pathogenesis of coronavirus disease 19 (COVID-19). Human β-defensins (hBDs) are among these AMPs, but the evidence is not well detailed. Therefore, this… read more here.
Keywords: hbd2; hbd4; covid; beta defensins ... See more keywords
Increased expression of miR146a dysregulates TLR2-induced HBD2 in airway epithelial cells from patients with COPD
Sign Up to like & getrecommendations! Published in 2023 at "ERJ Open Research"
DOI: 10.1183/23120541.00694-2022
Abstract: Background Airway epithelial cells from patients with COPD show suboptimal innate immune responses to nontypeable Haemophilus influenzae (NTHi) and Toll-like receptor (TLR)2 ligands despite expressing TLR2 similar to normal airway epithelial cells, but the underlying… read more here.
Keywords: hbd2; increased expression; airway epithelial; expression ... See more keywords
The Antimicrobial Peptide Human Beta-Defensin 2 Inhibits Biofilm Production of Pseudomonas aeruginosa Without Compromising Metabolic Activity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00805
Abstract: Biofilm production is a key virulence factor that facilitates bacterial colonization on host surfaces and is regulated by complex pathways, including quorum sensing, that also control pigment production, among others. To limit colonization, epithelial cells,… read more here.
Keywords: hbd2; metabolic activity; biofilm production; biofilm ... See more keywords