Toll‐like receptors, long non‐coding RNA NEAT1, and RIG‐I expression are associated with HBeAg‐positive chronic hepatitis B patients in the active phase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22886
Abstract: Innate immunity plays a crucial role in host‐virus interactions and greatly influences viral replication including HBV infection. However, few studies have investigated the possible antiviral immune roles played by TLRs, RIG‐I, and long no‐coding RNA… read more here.
Keywords: rna neat1; rig; hbeag positive; patients active ... See more keywords
Impact of nonalcoholic fatty liver disease status change on antiviral efficacy of nucleos(t)ide analogues in HBeAg‐positive chronic hepatitis B
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28501
Abstract: Data on the dynamic changes in chronic hepatitis B (CHB) patients with nonalcoholic fatty liver disease (NAFLD) during antiviral therapy are scarce. We aimed to investigate the evolution of NAFLD status change in CHB patients… read more here.
Keywords: nonalcoholic fatty; chb patients; hbeag positive; chronic hepatitis ... See more keywords
Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT
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DOI: 10.1080/21505594.2022.2158710
Abstract: ABSTRACT The purpose of this study was to develop an effective and non-invasive nomogram for evaluating liver obvious inflammation in untreated HBeAg positive patients with chronic hepatitis B virus (HBV) infection. A nomogram was established… read more here.
Keywords: inflammation; hbeag positive; chronic hepatitis; hepatitis virus ... See more keywords
Clinical Features of Chronic Hepatitis B in Treatment-naive Asian Patients With Positive HBeAg and Coexisting Precore and/or Basal Core Promoter Mutations
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DOI: 10.1097/mcg.0000000000000664
Abstract: Background: Precore or/and basal core promoter (PC/BCP) mutations are frequently detected in hepatitis B e antigen (HBeAg)-negative patients, but little is known about their clinical significance in HBeAg-positive patients. Aim: To characterize and report the… read more here.
Keywords: positive patients; hbeag positive; treatment naive; bcp mutations ... See more keywords
Consolidation period of 18 months no better at promoting off-treatment durability in HBeAg-positive chronic hepatitis B patients with tenofovir disoproxil fumarate treatment than a 12-month period
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DOI: 10.1097/md.0000000000019907
Abstract: Abstract There has been no clear consensus on the optimal consolidation periods following HBeAg seroconversion (SC) in HBeAg-positive chronic hepatitis B (CHB) patients. Our study aimed to prospectively compare relapse rates between 12 months’ and… read more here.
Keywords: treatment; period; consolidation period; consolidation ... See more keywords
Serum qAnti‐HBc combined with ALT and HBsAg predicts significant hepatic inflammation in HBeAg‐positive immune active patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.15881
Abstract: Quantitative hepatitis B core antibody (qAnti‐HBc) level has been reported to predict significant liver inflammation in treatment‐naïve chronic hepatitis B patients. However, little evidence has been revealed that qAnti‐HBc alone or with other serum parameters… read more here.
Keywords: hbeag positive; qanti hbc; hbc; hepatic inflammation ... See more keywords
Delayed viral suppression during antiviral therapy is associated with increased hepatocellular carcinoma rates in HBeAg‐positive high viral load chronic hepatitis B
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DOI: 10.1111/jvh.12838
Abstract: The treatment option in chronic hepatitis B (CHB) patients with persistent low‐level viremia despite entecavir or tenofovir monotherapy is unclear. This study investigated the development of hepatocellular carcinoma (HCC) or cirrhosis in hepatitis B e… read more here.
Keywords: suppression; hepatitis; hbeag positive; high viral ... See more keywords
Circulating BAFF and CXCL10 levels predict response to pegylated interferon in patients with HBeAg-positive chronic hepatitis B.
Sign Up to like & getrecommendations! Published in 2019 at "Asian Pacific journal of allergy and immunology"
DOI: 10.12932/ap-050718-0365
Abstract: BACKGROUND B-cell activating factor (BAFF), an essential cytokine for B lymphocytes activation, has been implicated in the pathogenesis of chronic viral hepatitis. However, the role of BAFF in patients with chronic hepatitis B (CHB) undergoing… read more here.
Keywords: cxcl10; treatment; patients hbeag; baff ... See more keywords
On-treatment HBV DNA dynamics predict virological breakthrough in entecavir-treated HBeAg-positive chronic hepatitis B
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DOI: 10.1371/journal.pone.0174046
Abstract: Background & aims Virological breakthrough (VBT) could be a manifestation of chronic hepatitis B (CHB) in patients treated with long-term nucleot(s)ide analogues. We aimed to determine the association of on-treatment serum hepatitis B virus (HBV)… read more here.
Keywords: hepatitis; hbeag positive; vbt group; treated hbeag ... See more keywords
No association between IFNL3 (IL28B) genotype and response to peginterferon alfa-2a in HBeAg-positive or -negative chronic hepatitis B
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DOI: 10.1371/journal.pone.0199198
Abstract: Background & aims It has yet to be firmly established whether host IFNL3 (IL28B) genotype influences interferon responsiveness in patients with chronic hepatitis B. We investigated associations between single-nucleotide polymorphisms (SNPs) in the IFNL3 region… read more here.
Keywords: response; hepatitis; hbeag positive; genotype ... See more keywords
Serum HBsAg and HBcrAg is associated with inflammation in HBeAg-positive chronic hepatitis B patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1083912
Abstract: Backgrounds & aims Liver inflammation is the main risk factor for developing liver fibrosis, cirrhosis, and even hepatocellular carcinoma in chronic hepatitis B (CHB) patients. To replace biopsy, additional non-invasive biomarkers to diagnose and grade… read more here.
Keywords: serum hbsag; inflammation; hbeag positive; hbsag hbcrag ... See more keywords