Association of polymorphisms in the HBG1‐HBD intergenic region with HbF levels
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23243
Abstract: Increased levels of fetal hemoglobin (HbF) can improve the clinical course of the patients with sickle cell anemia (SCA) or β‐thalassemia. The HBG1‐HBD intergenic region plays an important role in this process. However, very few… read more here.
Keywords: hbf; association polymorphisms; intergenic region; hbg1 hbd ... See more keywords
Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2021.03.005
Abstract: The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β-thalassemia and sickle cell anemia, two major global health problems. Although significant… read more here.
Keywords: hbf; erf; epigenetic inactivation; thalassemia ... See more keywords
Efficacy of entomopathogenic nematode and Bacillus thuringiensis combinations against Holotrichia parallela (Coleoptera: Scarabaeidae) larvae
Sign Up to like & getrecommendations! Published in 2021 at "Biological Control"
DOI: 10.1016/j.biocontrol.2020.104469
Abstract: Abstract The larvae of Holotrichia parallela Motschulsky (Coleoptera: Scarabaeidae) are notorious soil insect pests that cause severe damage to crop production in China. However, the long-term use of insecticides seriously pollutes the environment and threatens… read more here.
Keywords: larvae; beicherriana strain; hbf; holotrichia parallela ... See more keywords
Fetal hemoglobin levels in premature newborns. Should we reconsider transfusion of adult donor blood?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2021.04.018
Abstract: PURPOSE The aim of this study was to assess the percent decrease in fetal hemoglobin (HbF) after transfusion of adult-derived donor packed red blood cell (pRBC) units in extremely low gestational age newborns (ELGANs). METHODS… read more here.
Keywords: hbf; hemoglobin; blood; fetal hemoglobin ... See more keywords
Recherche et quantification de l’hémorragie fœto-maternelle par cytométrie en flux avec double marquage antihémoglobine F et anti-anhydrase carbonique
Sign Up to like & getrecommendations! Published in 2017 at "Transfusion Clinique Et Biologique"
DOI: 10.1016/j.tracli.2017.06.189
Abstract: Objectif Evaluer un kit de detection et quantification de l’hemorragie fœto-maternelle par cytometrie en flux utilisant un double marquage antihemoglobine fœtale (anti-HbF) et anti-anhydrase carbonique (anti-AC). Materiel & methode Vingt-neuf prelevements de femmes enceintes, dont… read more here.
Keywords: double marquage; hbf; anti; avec reactif ... See more keywords
Lower foetal haemoglobin levels at 31- and 34-weeks post menstrual age is associated with the development of retinopathy of prematurity
Sign Up to like & getrecommendations! Published in 2020 at "Eye"
DOI: 10.1038/s41433-020-0938-5
Abstract: Background/objectives Previous studies have suggested that lower mean foetal haemoglobin (HbF) levels is associated with an increased risk for developing retinopathy of prematurity (ROP). Lower HbF levels may lead to high oxygen exposure to the… read more here.
Keywords: hbf; age; rop; hbf levels ... See more keywords
CRISPR/Cas9-edited HSPC therapy for hemoglobinopathies
Sign Up to like & getrecommendations! Published in 2019 at "Lab Animal"
DOI: 10.1038/s41684-019-0406-7
Abstract: β-hemoglobinopathies are inherited disorders caused by mutations in the β-globin gene. Sickle cell disease, for example, is the result of deficient hemoglobin (Hb); patients with β-thalassemia produce insufficient amounts of the oxygen-carrying protein. To date,… read more here.
Keywords: hbf; crispr cas9; cas9 edited; gene ... See more keywords
Unusual stability exhibited by (AT)XN12(AT)Y motif associated with high fetal hemoglobin levels
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1532320
Abstract: Abstract Quasi-palindromic sequences (AT)XN12(AT)Y present in HS2 (hypersensitive site 2) of the human β-globin locus are known to be significantly associated with increased fetal hemoglobin (HbF) levels. High HbF levels in some adults arise due… read more here.
Keywords: xn12; hbf; fetal hemoglobin; unusual stability ... See more keywords
Targeting fetal hemoglobin expression to treat β hemoglobinopathies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2066519
Abstract: ABSTRACT Introduction Sickle cell disease and β thalassemia are the principal β hemoglobinopathies. The complex pathophysiology of sickle cell disease is initiated by sickle hemoglobin polymerization. In β thalassemia, insufficient β-globin synthesis results in excessive… read more here.
Keywords: thalassemia; hbf; cell disease; sickle cell ... See more keywords
The state of the art of fetal hemoglobin-inducing agents
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2141708
Abstract: ABSTRACT Introduction Sickle cell anemia (SCA) is a hematological genetic disorder caused by a mutation in the gene of the β-globin. Pharmacological treatments will continue to be an important approach, including the strategy to induce… read more here.
Keywords: new drugs; art fetal; hbf; state art ... See more keywords
Mutation Screening of the Krüppel-like Factor 1 Gene in Individuals With Increased Fetal Hemoglobin Referred for Hemoglobinopathy Investigation in South of Iran
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001093
Abstract: Background: Any mutation in the Krüppel-like factor 1 (KLF1) gene may interfere with its proper related function in the erythropoiesis process and lead to alterations in proper activation of its downstream protein through globin switching,… read more here.
Keywords: hbf; individuals increased; fetal hemoglobin; gene ... See more keywords