miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A
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DOI: 10.1007/s11033-020-05483-7
Abstract: Patients with β-thalassemia suffer from a lack or absence of the beta-globin chain of normal hemoglobin (Hb). Therefore, an increase in fetal Hb (HbF) levels could improve the clinical status of these patients. Downregulation of… read more here.
Keywords: mir 30a; bcl11a; expression; hbf levels ... See more keywords
Insight of fetal to adult hemoglobin switch: Genetic modulators and therapeutic targets.
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DOI: 10.1016/j.blre.2021.100823
Abstract: The clinical heterogeneity of β-hemoglobinopathies is so variable that it prompted the researchers to identify the genetic modulators of these diseases. Though the primary modulator is the type of β-globin mutation which affects the degree… read more here.
Keywords: insight fetal; hemoglobin; therapeutic targets; genetic modulators ... See more keywords
Lower foetal haemoglobin levels at 31- and 34-weeks post menstrual age is associated with the development of retinopathy of prematurity
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DOI: 10.1038/s41433-020-0938-5
Abstract: Background/objectives Previous studies have suggested that lower mean foetal haemoglobin (HbF) levels is associated with an increased risk for developing retinopathy of prematurity (ROP). Lower HbF levels may lead to high oxygen exposure to the… read more here.
Keywords: hbf; age; rop; hbf levels ... See more keywords
The HBG2 rs7482144 (C > T) Polymorphism is Linked to HbF Levels but not to the Severity of Sickle Cell Anemia
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DOI: 10.1055/s-0041-1733950
Abstract: Sickle cell anemia (SCA) is a severe disease characterized by anemia, acute clinical complications, and a relatively short life span. In this disease, abnormal hemoglobin makes the red blood cells deformed, rigid, and sticky. Fetal… read more here.
Keywords: hbg2 rs7482144; rs7482144 polymorphism; severity; hbf levels ... See more keywords
Alterations on high HbF levels may be associated with KLF1 gene mutations.
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DOI: 10.14715/klf1;
Abstract: The KLF1 gene synthesizes a transcription factor in the zinc finger structure that regulates the transcription of β-, γ-globin, and Foxm1 genes. This factor plays an important role in the erythropoiesis mechanism by modifying the… read more here.
Keywords: high hbf; hbf; globin gene; klf1 gene ... See more keywords
Association Between Selected Single Nucleotide Polymorphisms in Globin and Related Genes and Response to Hydroxyurea Therapy in Ghanaian Children with Sickle Cell Disease
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DOI: 10.2147/pgpm.s351599
Abstract: Background Sickle cell disease (SCD) is a group of genetic disorders affecting the structure and function of haemoglobin. Hydroxyurea (HU) stimulates fetal haemoglobin (HbF) and reduces sickle erythrocyte-endothelial cell interaction. However, the degree of HbF… read more here.
Keywords: cell; rs11886868 rs6706648; snps; hbf ... See more keywords