Multiplex CRISPR/Cas9 Genome Editing Targeting the BCL11A/HBG Axis Maximizes Fetal Hemoglobin Reinduction but Generates Chromosomal Translocations Which Persist In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-138539
Abstract: Sickle cell disease and β-thalassemia are among the most common monogenic disorders globally, causing significant morbidity and early mortality. The only curative option available is allogeneic hematopoietic stem cell transplantation, which is limited by a… read more here.
Keywords: genome editing; reinduction; crispr cas9; bcl11a ... See more keywords
Relevance of β-Glucan Molecular Properties on Its Suitability as Health Promoting Bread Ingredient
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DOI: 10.3390/nu14081570
Abstract: The fate of β-glucan (BG) health promoting properties during food production is crucial, but not predictable yet. Therefore, high molar mass BG (hBG) and control BG (cBG) were extracted from two barley varieties, characterized and… read more here.
Keywords: cbg; health; hbg; molar mass ... See more keywords