Articles with "hbg1" as a keyword



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New Deletion at Promoter of HBG1 Gene in Sickle Cell Disease Patients With High HbF Level

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Published in 2019 at "Journal of Pediatric Hematology/Oncology"

DOI: 10.1097/mph.0000000000001626

Abstract: Objectives: The 5′ upstream region of the HBG1 gene plays a very important role in the expression of fetal hemoglobin (HbF). In contrast, increased HbF levels can inhibit the deoxygenation-induced polymerization of sickle hemoglobin (α2βS2),… read more here.

Keywords: deletion; hbg1; promoter; sickle cell ... See more keywords
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A Single -195 C < G HBG1 Promoter Mediated By CRISPR/Cas9 Genome Editing Induces Fetal Hemoglobin Synthesis in Hudep-2

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Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-118534

Abstract: Sickle cell disease (SCD) is a serious condition, chronic and undoubtedly represents a public health problem worldwide. SCD is caused by a point mutation in codon 6 of the β globin gene resulting in the… read more here.

Keywords: crispr cas9; hbg1; hudep; hpfh ... See more keywords
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Negative regulation of HBG1/2 expression through S6K by long noncoding RNA NR_120526

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Published in 2023 at "Translational Pediatrics"

DOI: 10.21037/tp-23-174

Abstract: Background High levels of fetal hemoglobin (HbF) may alleviate clinical symptoms in patients with β-thalassemia. A previous study showed that the long noncoding RNA NR_120526 (lncRNA NR_120526) might be involved in regulating HbF levels (HBG1/2… read more here.

Keywords: hbg1; hbg1 expression; s6k; rna ... See more keywords