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Published in 2019 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001626
Abstract: Objectives: The 5′ upstream region of the HBG1 gene plays a very important role in the expression of fetal hemoglobin (HbF). In contrast, increased HbF levels can inhibit the deoxygenation-induced polymerization of sickle hemoglobin (α2βS2),…
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Keywords:
deletion;
hbg1;
promoter;
sickle cell ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-118534
Abstract: Sickle cell disease (SCD) is a serious condition, chronic and undoubtedly represents a public health problem worldwide. SCD is caused by a point mutation in codon 6 of the β globin gene resulting in the…
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Keywords:
crispr cas9;
hbg1;
hudep;
hpfh ... See more keywords
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Published in 2023 at "Translational Pediatrics"
DOI: 10.21037/tp-23-174
Abstract: Background High levels of fetal hemoglobin (HbF) may alleviate clinical symptoms in patients with β-thalassemia. A previous study showed that the long noncoding RNA NR_120526 (lncRNA NR_120526) might be involved in regulating HbF levels (HBG1/2…
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Keywords:
hbg1;
hbg1 expression;
s6k;
rna ... See more keywords