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   Articles with "hbha" as a keyword



Characterization of the HBHA response in TB patients with or without HIV infection

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recommendations! Published in 2017 at "European Respiratory Journal"

DOI: 10.1183/1393003.congress-2017.pa3039

Abstract: Introduction: It would be important to identify subjects at risk to develop tuberculosis (TB) disease. RD1-based Interferon-γ Release Assays (IGRAs) cannot distinguish latent from active TB disease. Conversely, a positive response to HBHA-based IGRAs, among… read more here.

Keywords: response; hiv uninfected; hiv; infection ... See more keywords

Immunogenicity of heparin-binding hemagglutinin expressed by Pichia pastoris GS115 strain

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recommendations! Published in 2018 at "Iranian Journal of Basic Medical Sciences"

DOI: 10.22038/ijbms.2018.24280.6064

Abstract: Objective(s): Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain… read more here.

Keywords: immunogenicity; hbha; pastoris gs115; tuberculosis ... See more keywords

Immuno-Diagnosis of Active Tuberculosis by a Combination of Cytokines/Chemokines Induced by Two Stage-Specific Mycobacterial Antigens: A Pilot Study in a Low TB Incidence Country

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.842604

Abstract: Active tuberculosis (aTB) remains a major killer from infectious disease, partially due to delayed diagnosis and hence treatment. Classical microbiological methods are slow and lack sensitivity, molecular techniques are costly and often unavailable. Moreover, available… read more here.

Keywords: infected subjects; hbha; validation; non infected ... See more keywords

HBHA-ECSIT interaction disrupts macrophage autophagy to promote Mycobacterium tuberculosis persistence

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1596568

Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the most significant global health challenges exacerbated by latent tuberculosis infection (LTBI). Heparin-binding hemagglutinin (HBHA), a virulence factor of Mtb, plays a critical role in… read more here.

Keywords: ecsit; persistence; mycobacterium tuberculosis; hbha ... See more keywords