Long‐term outcomes and predictive scores for hepatocellular carcinoma and hepatitis B surface antigen seroclearance after hepatitis B e‐antigen seroclearance
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DOI: 10.1002/hep.29874
Abstract: The significance of hepatitis B e‐antigen (HBeAg) seroclearance (ESC) in the long term is not well defined. The current study aimed to determine the clinical outcomes, the factors and predictive scores for hepatocellular carcinoma (HCC),… read more here.
Keywords: hepatitis; esc; antigen; predictive scores ... See more keywords
HBV transcription and translation persist despite viral suppression in HBV‐HIV co‐infected patients on antiretroviral therapy
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DOI: 10.1002/hep.32634
Abstract: Background and aims: Liver injury may persist in patients with HBV receiving antiviral therapy who have ongoing transcription and translation. We sought to assess ongoing HBV transcription by serum HBV RNA, translation by serum hepatitis… read more here.
Keywords: hbv rna; hiv; hbsag; hbv ... See more keywords
HBsAg mutations related to occult hepatitis B virus infection in HIV‐positive patients result in a reduced secretion and conformational changes of HBsAg
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DOI: 10.1002/jmv.24623
Abstract: Background: Occult hepatitis B infection (OBI) is a frequent finding in human immunodeficiency virus (HIV)‐infected patients. While several related mutations in the hepatitis B virus (HBV) genome have been reported, their distinct impact on HBsAg… read more here.
Keywords: hiv; occult hepatitis; conformational changes; hepatitis virus ... See more keywords
Resolution of HBV infection occurs sooner than recovery of renal disease in adult serum HBsAg‐negative HBV–associated glomerulonephritis
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DOI: 10.1002/jmv.25211
Abstract: Most cases of hepatitis B virus–associated glomerulonephritis (HBV‐GN) occur in children and present with serum HBsAg positivity. Few studies have investigated adult patients with HBV‐GN who are serum HBsAg‐negative. This study aimed to determine the… read more here.
Keywords: adult; hbsag negative; serum hbsag; hbv ... See more keywords
Ubiquitin E3 ligase β‐TrCP negatively regulates surface protein of hepatitis B virus
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DOI: 10.1002/jmv.28620
Abstract: Chronic hepatitis B (CHB) still cannot be cured currently, while the pursuit of a functional cure seems to be an accessible goal, in which the condition mainly depends on the serum hepatitis B surface antigen… read more here.
Keywords: hbsag; trcp; ubiquitin ligase; hbsag levels ... See more keywords
High Genetic Variability of Hepatitis B Virus in Blood Donors With Surface Antigen Positive But DNA Negative in Southern China
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DOI: 10.1002/jmv.70396
Abstract: In our previous studies, 45.2% of donations with HBV HBsAg reactive (+) by ELISA but negative (−) by NAT were confirmed to have HBV infections in Shenzhen Blood Center, China. However, the serological and molecular… read more here.
Keywords: hbv; indeterminate results; blood; china ... See more keywords
Risk of viral reactivation in patients with occult hepatitis B virus infection during ruxolitinib treatment
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DOI: 10.1007/s00277-018-3405-7
Abstract: Dear Editor, Janus kinases (JAKs) are a family of cytoplasmic non-receptor tyrosine kinases (JAK1, JAK2, JAK3, TYK2) associated with cytokine receptors lacking intrinsic kinase activities. Ligand binding to these cytokine receptors activates JAKs, resulting in… read more here.
Keywords: dna; treatment; hbv; reactivation ... See more keywords
Generation of HBsAg DNA aptamer using modified cell-based SELEX strategy.
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DOI: 10.1007/s11033-020-05995-2
Abstract: Aptamers as potential alternatives for antibodies could be employed against hepatitis B surface antigen (HBsAg), the great hallmark and first serological marker in HBV, for further theragnostic applications. Therefore, isolation HBsAg specific aptamer was performed… read more here.
Keywords: based selex; modified cell; cell selex; cell based ... See more keywords
Design of aptamer-based sensing platform using gold nanoparticles functionalized reduced graphene oxide for ultrasensitive detection of Hepatitis B virus
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DOI: 10.1007/s11696-020-01292-1
Abstract: In the present work, electrochemical aptasensor for earlier detection of Hepatitis B virus infection was developed. First, the surface of a glassy carbon electrode was modified with gold nanoparticles functionalized reduced graphene oxide, then thiol-terminated… read more here.
Keywords: detection; gold nanoparticles; aptasensor; detection hepatitis ... See more keywords
Use of HBsAg quantification in the natural history and treatment of chronic hepatitis B
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DOI: 10.1007/s12072-019-09998-5
Abstract: In patients with chronic hepatitis B (CHB) infection, it is important to monitor the natural history, assess treatment response, and predict the risk of liver-related complications. Quantification of serum hepatitis B surface antigen (HBsAg) has… read more here.
Keywords: hepatitis; treatment; natural history; chronic hepatitis ... See more keywords
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element
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DOI: 10.1016/j.antiviral.2017.11.009
Abstract: ABSTRACT In pursuit of novel therapeutics targeting the hepatitis B virus (HBV) infection, we evaluated a dihydroquinolizinone compound (DHQ‐1) that in the nanomolar range reduced the production of virion and surface protein (HBsAg) in tissue… read more here.
Keywords: rna; hbv; regulatory element; hbsag mrna ... See more keywords