Combined DTP-HBV vaccine versus separately administered DTP and HBV vaccines for primary prevention of diphtheria, tetanus, pertussis, and hepatitis B
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DOI: 10.1002/14651858.cd008658.pub2
Abstract: Reason for withdrawal from publication This protocol has been withdrawn from the Cochrane Library as the authors were not able to complete the review. read more here.
Keywords: hbv vaccine; dtp hbv; versus separately; hbv ... See more keywords
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1
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DOI: 10.1002/advs.202103135
Abstract: Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in the nucleus and is resistant to antiviral agents. Identification… read more here.
Keywords: circular dna; hbv; transcription; covalently closed ... See more keywords
Prophylactic and therapeutic HBV vaccination by an HBs‐expressing cytomegalovirus vector lacking an interferon antagonist in mice
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DOI: 10.1002/eji.202048780
Abstract: Cytomegalovirus (CMV)‐based vaccines show promising effects against chronic infections in nonhuman primates. Therefore, we examined the potential of hepatitis B virus (HBV) vaccines based on mouse CMV (MCMV) vectors expressing the small HBsAg. Immunological consequences… read more here.
Keywords: hbs; hbv; prophylactic therapeutic; cytomegalovirus ... See more keywords
A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins
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DOI: 10.1002/hep.28952
Abstract: Introduction of direct‐acting antivirals against hepatitis C virus (HCV) has provided a revolutionary improvement in the treatment outcome. In contrast to HCV, however, the strategy for developing new antiviral agents against hepatitis B virus (HBV),… read more here.
Keywords: pac; hbv; large surface; hepatitis virus ... See more keywords
A novel quantitative microarray antibody capture assay identifies an extremely high hepatitis delta virus prevalence among hepatitis B virus–infected mongolians
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DOI: 10.1002/hep.28957
Abstract: Hepatitis delta virus (HDV) causes the most severe form of human viral hepatitis. HDV requires a hepatitis B virus (HBV) coinfection to provide HDV with HBV surface antigen envelope proteins. The net effect of HDV… read more here.
Keywords: antibody; hbv; prevalence; hdv ... See more keywords
Evaluating Noninvasive Markers to Identify Advanced Fibrosis by Liver Biopsy in HBV/HIV Co‐infected Adults
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DOI: 10.1002/hep.30825
Abstract: Noninvasive biomarkers are used increasingly to assess fibrosis in patients with chronic liver disease. We determined the utility of dual cutoffs for noninvasive biomarkers to exclude and confirm advanced fibrosis in hepatitis B virus (HBV)–human… read more here.
Keywords: vcte; fibrosis; hbv; advanced fibrosis ... See more keywords
HBV-TERT Promoter Integration Harnesses Host ELF4 Resulting in TERT Gene Transcription in Hepatocellular Carcinoma.
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DOI: 10.1002/hep.31231
Abstract: Hepatitis B virus (HBV) integrations are common in hepatocellular carcinoma (HCC). In particular, alterations of TERT gene by HBV integrations are frequent; however the molecular mechanism and functional consequence underlying TERT-HBV integration are unclear. We… read more here.
Keywords: transcription; integration; hbv; tert promoter ... See more keywords
Diverse facets of MDSC in different phases of chronic HBV infection: Impact on HBV‐specific T‐cell response and homing
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DOI: 10.1002/hep.32331
Abstract: Chronic HBV infection (CHI) is associated with a diverse natural history that includes immune‐tolerant (IT), HBeAg‐positive chronic hepatitis B (CHB) (EP‐CHB), inactive carrier, and HBeAg‐negative CHB (EN‐CHB) phases. A hallmark of CHI is impairment of… read more here.
Keywords: cell response; specific cell; hbv; hbv specific ... See more keywords
Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B
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DOI: 10.1002/hep.32614
Abstract: Background and Aims: In the treatment of chronic hepatitis B (CHB) infection, stimulation of innate immunity may lead to hepatitis B virus (HBV) cure. Alpha‐kinase 1 (ALPK1) is a pattern recognition receptor (PRR) that activates… read more here.
Keywords: phh; hbv; mouse; efficacy ... See more keywords
Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells
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DOI: 10.1002/hep.32622
Abstract: Background and Aims: Murine hepatic cells cannot support hepatitis B virus (HBV) infection even with supplemental expression of viral receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). However, the specific restricted step remains elusive. In this… read more here.
Keywords: hepatic cells; hbv; murine hepatic; infection ... See more keywords
HBV transcription and translation persist despite viral suppression in HBV‐HIV co‐infected patients on antiretroviral therapy
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DOI: 10.1002/hep.32634
Abstract: Background and aims: Liver injury may persist in patients with HBV receiving antiviral therapy who have ongoing transcription and translation. We sought to assess ongoing HBV transcription by serum HBV RNA, translation by serum hepatitis… read more here.
Keywords: hbv rna; hiv; hbsag; hbv ... See more keywords