Live Cell Imaging Reveals HBV Capsid Translocation from the Nucleus To the Cytoplasm Enabled by Cell Division
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DOI: 10.1128/mbio.03303-22
Abstract: Hepatitis B virus (HBV) is an enveloped, reverse-transcribing DNA virus that is a major cause of liver disease and hepatocellular carcinoma. Subcellular trafficking events underpinning HBV capsid assembly and virion egress remain poorly characterized. ABSTRACT… read more here.
Keywords: hbv capsid; cell; cell division; cell imaging ... See more keywords
Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model
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DOI: 10.3390/ph15070773
Abstract: Capsid assembly modulators (CAMs) have emerged as a promising class of antiviral agents. We studied the effects of twenty-one newly designed and synthesized CAMs including heteroaryldihydropyrimidine compounds (HAPs), their analogs and standard compounds on hepatitis… read more here.
Keywords: hbv capsid; assembly modulators; capsid assembly; capsid ... See more keywords
All-Atom MD Simulations of the HBV Capsid Complexed with AT130 Reveal Secondary and Tertiary Structural Changes and Mechanisms of Allostery
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DOI: 10.3390/v13040564
Abstract: The hepatitis B virus (HBV) capsid is an attractive drug target, relevant to combating viral hepatitis as a major public health concern. Among small molecules known to interfere with capsid assembly, the phenylpropenamides, including AT130,… read more here.
Keywords: simulations hbv; hbv capsid; atom simulations; reveal ... See more keywords