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   Articles with "hbv cccdna" as a keyword



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IFN-α2b inhibits the ethanol enriched-HBV cccDNA through blocking a positive feedback loop of HBx/MSL2/cccDNA/HBV/HBx in liver.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.04.057

Abstract: Hepatitis B virus (HBV) is a major risk factor for liver diseases, in which HBV covalently closed circular DNA (cccDNA), as the genomic form that templates viral transcription, plays crucial roles in sustaining viral persistence.… read more here.

Keywords: cccdna; hbv; liver; cccdna hbv ... See more keywords

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.

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recommendations! Published in 2022 at "Gut"

DOI: 10.1136/gutjnl-2020-323665

Abstract: OBJECTIVES Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently close circular (ccc)DNA, not targeted by… read more here.

Keywords: cell based; cccdna host; reporter assay; hbv cccdna ... See more keywords

IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA

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recommendations! Published in 2020 at "Clinical Epigenetics"

DOI: 10.1186/s13148-020-00928-z

Abstract: Background Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, displaying succinyltransferase activity, is recruited onto… read more here.

Keywords: gcn5; cccdna; cccdna minichromosome; succinylation ... See more keywords
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Gene Editing Technologies to Target HBV cccDNA

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14122654

Abstract: Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma. Current licensed therapies against HBV efficiently suppress viral… read more here.

Keywords: hbv cccdna; gene editing; target hbv; editing technologies ... See more keywords