A Galactose-Engineered Dual-Responsive Nanocarrier for ASO/CRISPR-Cas9 Delivery to Inhibit HBV Replication.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502835
Abstract: Complete hepatitis B virus (HBV) cure is hindered primarily by the stable persistence of covalently closed circular DNA (cccDNA). Gene editing approaches to eradicate HBV by targeting cccDNA face challenges and limitations due to suboptimal… read more here.
Keywords: hbv replication; hbv; delivery; crispr cas9 ... See more keywords
Effect of mutations across reverse transcriptase region on HBV replication and progression of liver diseases in Chinese patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24530
Abstract: It was known that mutations in the RT region were mainly related to nucleot(s)ide analogs resistance. Increasing studies indicated that RT mutations were related to advanced liver diseases (ALD) and had effects on HBV replication,… read more here.
Keywords: effect; hbv replication; region; liver diseases ... See more keywords
GP73 facilitates hepatitis B virus replication by repressing the NF‐κB signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25718
Abstract: Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, and 600 000 deaths are caused by HBV‐related hepatic failure. Golgi protein 73 (GP73) is a serum biomarker for liver diseases, including chronic hepatitis B.… read more here.
Keywords: gp73; hbv replication; gp73 facilitates; hepatitis virus ... See more keywords
TIM22 and TIM29 inhibit HBV replication by up‐regulating SRSF1 expression
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29439
Abstract: Hepatitis B virus (HBV) infection is a serious global health problem. After the viruses infect the human body, the host can respond to the virus infection by coordinating various cellular responses, in which mitochondria play… read more here.
Keywords: tim22 tim29; hbv replication; infection;
Novel Function of NUP153 in HNF4α Transcriptional Upregulation Contributes to Promoting HBV Replication
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70256
Abstract: Hepatitis B virus (HBV) infection remains a major public health problem, causing nearly one million deaths annually. Nucleoporin 153 (NUP153) is known to facilitate the nuclear entry of the human immunodeficiency virus (HIV) nucleocapsids, and… read more here.
Keywords: replication; upregulation; function nup153; hbv replication ... See more keywords
BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3900-0
Abstract: The high prevalence (14.3%) of HIV/HBV co-infections reported in west China makes it necessary to screen concurrent HBV infection in HIV carriers. HBV B genotype was shown to be dominant in 54 cases of HIV/HBV… read more here.
Keywords: hiv hbv; hiv; hbv; prevalence ... See more keywords
HBV replication inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104815
Abstract: Chronic Hepatitis B Virus infections afflict >250 million people and kill nearly 1 million annually. Current non-curative therapies are dominated by nucleos(t)ide analogs (NAs) that profoundly but incompletely suppress DNA synthesis by the viral reverse… read more here.
Keywords: inhibitors hbv; hbv replication; replication inhibitors; hbv reverse ... See more keywords
Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.12.008
Abstract: ABSTRACT Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV‐infected patients receiving chemotherapy are at risk of HBV reactivation… read more here.
Keywords: ros jnk; cisplatin; hbv replication; mtor ... See more keywords
Distinct role of 4E‐BP1 and S6K1 in regulating autophagy and hepatitis B virus (HBV) replication
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.01.039
Abstract: Aims: To investigate the role and underlying mechanism of 4E‐BP1 and S6K1 in regulating autophagy and hepatitis B virus (HBV) replication. Main methods: The mRNA relative expression of HBx and its DNA level were detected… read more here.
Keywords: bp1 s6k1; replication; hbv replication; microscopy ... See more keywords
A primary human hepatocyte/hepatic stellate cell co-culture system for improved in vitro HBV replication.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.03.012
Abstract: Primary human hepatocytes (PHHs) are considered the gold standard for the in vitro study of HBV replication as they directly reflect the metabolism and functionality of the human liver. However, several limitations of this system… read more here.
Keywords: system; hbv; hbv replication; primary human ... See more keywords
NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription
Sign Up to like & getrecommendations! Published in 2021 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1869388
Abstract: ABSTRACT Nuclear factor of activated T cells 3 (NFATc3) has been reported to upregulate type I interferons (IFNs) expression, and the abnormal expression and activation of NFATc3 were closely related to tumorigenesis. However, the potential… read more here.
Keywords: inhibits hepatocarcinogenesis; hbv replication; rig mediated; rig ... See more keywords