Serum Hepatitis B Virus RNA: A New Potential Biomarker for Chronic Hepatitis B Virus Infection
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30325
Abstract: Chronic hepatitis B infection is one of the major etiological causes of liver failure, cirrhosis, and hepatocellular carcinoma (HCC) worldwide. This condition cannot be completely cured by currently available drugs due to the persistent existence… read more here.
Keywords: hepatitis; hbv rna; hepatitis virus; serum ... See more keywords
Reply to "Can the ratio of serum HBV RNA to DNA reflect the reverse transcription efficiency of viral pgRNA?"
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31689
Abstract: We thank Li et al for their interest regarding our article reporting the profile of serum HBV RNA in patients with chronic hepatitis B infection. In our study, we used a relatively established assay that… read more here.
Keywords: reply ratio; hbv rna; rna; serum hbv ... See more keywords
HBV transcription and translation persist despite viral suppression in HBV‐HIV co‐infected patients on antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32634
Abstract: Background and aims: Liver injury may persist in patients with HBV receiving antiviral therapy who have ongoing transcription and translation. We sought to assess ongoing HBV transcription by serum HBV RNA, translation by serum hepatitis… read more here.
Keywords: hbv rna; hiv; hbsag; hbv ... See more keywords
Nucleos(t)ide analogues altered quasispecies composition of hepatitis B virus (HBV)‐resistant mutations in serum HBV DNA and serum HBV RNA
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28612
Abstract: Serum hepatitis B virus (HBV) RNA is a new serological indicator reflecting viral replication with good clinical application prospects. This study aimed to clarify the dynamic changes of serum HBV RNA levels and the quasispecies… read more here.
Keywords: hbv rna; hbv dna; serum hbv;
Developing an Accurate Assay for Detection of Serum HBV RNA and SP1 Variant in CHB Based on Long‐Read Sequencing
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70676
Abstract: The profiles of spliced pgRNA variants in NAs‐treated HBV‐infected patients were still unclear, and the sensitivity and accuracy of quantification of HBV RNA or spliced pgRNA variants 1 (SP1) needs improvement. In this study, we… read more here.
Keywords: hbv; read sequencing; long read; spliced pgrna ... See more keywords
Highly Sensitive Detection of HBV RNA in Liver Tissue by In Situ Hybridization.
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DOI: 10.1007/978-1-4939-6700-1_10
Abstract: As soon as HBV was identified, HBV localization at the cellular level became instrumental in studying HBV infection. Multiple methodologies for detection of viral antigens and nucleic acids at the cellular level, not only in… read more here.
Keywords: detection; hbv rna; hbv; tissue ... See more keywords
Relationship between serum HBV-RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.08.021
Abstract: BACKGROUND & AIMS In diagnostics, serum hepatitis B virus (HBV)-RNA levels are valuable when the HBV-DNA load in circulation is effectively suppressed by nucleos(t)ide analogue (NUC) therapy. This study aimed to determine the intrahepatic viral… read more here.
Keywords: hbv rna; hbv; rna levels; intrahepatic viral ... See more keywords
Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c01981
Abstract: Approved therapies for hepatitis B virus (HBV) treatment include nucleos(t)ides and interferon alpha (IFN-α) which effectively suppress viral replication, but they rarely lead to cure. Expression of viral proteins, especially surface antigen of the hepatitis… read more here.
Keywords: hbv; structure activity; rna destabilizer; hbv rna ... See more keywords
MCPIP1 reduces HBV-RNA by targeting its epsilon structure
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DOI: 10.1038/s41598-020-77166-z
Abstract: Hepatitis B virus (HBV) is the major causative factor of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. We previously demonstrated that a proinflammatory cytokine IL-1β reduced the level of HBV RNA. However, the mechanism… read more here.
Keywords: hbv rna; mcpip1; epsilon structure;
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.
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DOI: 10.1053/j.gastro.2017.10.017
Abstract: BACKGROUND & AIMS NVR3-778 is a capsid assembly modulator in clinical development. We determined the in vivo antiviral efficacy and effects on innate and endoplasmic reticulum (ER) stress responses of NVR3-778 alone or in combination with… read more here.
Keywords: dna; hbv rna; hbv; nvr3 778 ... See more keywords
Use of HBV RNA and hepatitis B core-related antigen to predict change in serological status and disease activity in CHB.
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DOI: 10.1097/hep.0000000000000413
Abstract: BACKGROUND AND AIMS Predicting changes in disease activity and serological endpoints is necessary for management of patients with chronic hepatitis B (CHB). We examined whether HBV RNA and hepatitis B core-related antigen (HBcrAg), two specialized… read more here.
Keywords: loss; hbv rna; activity; hepatitis ... See more keywords