Diverse facets of MDSC in different phases of chronic HBV infection: Impact on HBV‐specific T‐cell response and homing
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32331
Abstract: Chronic HBV infection (CHI) is associated with a diverse natural history that includes immune‐tolerant (IT), HBeAg‐positive chronic hepatitis B (CHB) (EP‐CHB), inactive carrier, and HBeAg‐negative CHB (EN‐CHB) phases. A hallmark of CHI is impairment of… read more here.
Keywords: cell response; specific cell; hbv; hbv specific ... See more keywords
Strategies to overcome HBV-specific T cell exhaustion: checkpoint inhibitors and metabolic re-programming.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2018.01.003
Abstract: HBV-specific T cells play a key role in antiviral protection and failure to control HBV is associated with severely dysfunctional T cell responses. Therefore, functional T cell reconstitution represents a potential way to treat chronically… read more here.
Keywords: hbv; checkpoint; hbv specific; cell ... See more keywords
The impact of HBsAg reduction via siRNA treatment on natural and vaccine (BRII-179)-induced HBV-specific humoral and cellular immune responses.
Sign Up to like & getrecommendations! Published in 2025 at "Gastroenterology"
DOI: 10.1053/j.gastro.2025.02.016
Abstract: BACKGROUND AND AIMS The impact of HBsAg reduction from small interfering RNA (siRNA) treatments on HBV-specific immunity of CHB participants has not been adequately analyzed in human. We conducted a phase 2a study treating CHB… read more here.
Keywords: brii 179; vaccine brii; hbv specific; hbsag reduction ... See more keywords
An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1471312
Abstract: ABSTRACT Dendritic cells (DCs) play a predominant role in initiating cell immune responses. Here we generated a DC-targeting lentiviral vector (LVDC-UbHBcAg-LIGHT) and evaluated its capacity to elicit HBV-specific cytotoxic T lymphocyte (CTL) responses. DC-SIGN-mediated specific… read more here.
Keywords: lvdc ubhbcag; hbv; dendritic cells; hbv specific ... See more keywords
Interleukin-33 Reinvigorates Antiviral Function of Viral-Specific CD8+ T Cells in Chronic Hepatitis B Virus Infection.
Sign Up to like & getrecommendations! Published in 2021 at "Viral immunology"
DOI: 10.1089/vim.2021.0140
Abstract: Restoration of exhausted hepatitis B virus (HBV)-specific CD8+ T cells is one of the important strategies for inhibition of viral replication. The role of interleukin (IL)-33 to recovery of CD8+ T cell activity is not… read more here.
Keywords: specific cd8; cd8; hepatitis; cd8 cells ... See more keywords
Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Gut"
DOI: 10.1136/gutjnl-2022-327202
Abstract: Objective Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection are broadly heterogeneous. Characterisation of their functional impairment may allow to distinguish patients with different capacity to control infection and reconstitute antiviral… read more here.
Keywords: cell; hbv specific; cd8 cell; specific cd8 ... See more keywords
HBV-Specific TCR–T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regimen for Recurrent HBV-Related HCC after Liver Transplantation
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-25-1245
Abstract: Abstract Purpose: This study aimed to preliminarily evaluate the safety, tolerability, and antitumor efficacy of hepatitis B virus (HBV)-specific T-cell receptor (TCR)–T cell therapy combining mRNA electroporation and lentiviral transduction in patients with recurrent HBV–hepatocellular… read more here.
Keywords: treatment; tcr; hbv specific; tcr cells ... See more keywords
The Adaptive Immune Response in Hepatitis B Virus-Associated Hepatocellular Carcinoma Is Characterized by Dysfunctional and Exhausted HBV-Specific T Cells
Sign Up to like & getrecommendations! Published in 2024 at "Viruses"
DOI: 10.3390/v16050707
Abstract: This systematic review investigates the immunosuppressive environment in HBV-associated hepatocellular carcinoma (HCC), characterized by dysfunctional and exhausted HBV-specific T cells alongside an increased infiltration of HBV-specific CD4+ T cells, particularly regulatory T cells (Tregs). Heightened… read more here.
Keywords: hbv; associated hepatocellular; dysfunctional exhausted; characterized dysfunctional ... See more keywords