HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.128713
Abstract: Osteolytic bone lesions and hypercalcemia are common, serious complications in adult T cell leukemia/lymphoma (ATL), an aggressive T cell malignancy associated with human T cell leukemia virus type 1 (HTLV-1) infection. The HTLV-1 viral oncogene… read more here.
Keywords: bone; hbz; cell leukemia; bone destruction ... See more keywords
The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009919
Abstract: Viral infections are known to hijack the transcription and translation of the host cell. However, the extent to which viral proteins coordinate these perturbations remains unclear. Here we used a model system, the human T-cell… read more here.
Keywords: tax; tax hbz; mrna splicing; splicing landscape ... See more keywords
The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.939863
Abstract: Adult T-cell leukemia/lymphoma (ATL) is a T-cell lymphoproliferative neoplasm caused by the human T-cell leukemia virus type 1 (HTLV-1). Two viral proteins, Tax-1 and HBZ play important roles in HTLV-1 infectivity and in HTLV-1-associated pathologies… read more here.
Keywords: cell; rna splicing; endogenous hbz; hbz ... See more keywords
HTLV-1 basic leucine zipper factor downregulates cyclin D1 expression via interactions with NF-κB.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2017.2868
Abstract: Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the… read more here.
Keywords: htlv basic; cyclin expression; factor; hbz ... See more keywords