Histologic Chorioamnionitis and Neurodevelopment in Preterm Infants
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.31158
Abstract: Key Points Question Is histologic chorioamnionitis (HCA) associated with neurodevelopmental outcomes of premature infants (gestational age ≤32 weeks), independent of preterm birth? Findings In this cohort study of 304 infants, moderate to severe HCA was… read more here.
Keywords: neurodevelopment preterm; preterm infants; histologic chorioamnionitis; hca ... See more keywords
Synthesis and characterization of some new pyrazolines and their inhibitory potencies against carbonic anhydrases
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900292
Abstract: The inhibition of the two human cytosolic carbonic anhydrase (hCA; EC 4.2.1.1) isozymes I and II with some new pyrazoline derivatives was investigated for the first time. The structures of the newly synthesized pyrazoline derivatives… read more here.
Keywords: new pyrazolines; inhibitory potencies; characterization new; hca ... See more keywords
Synthesis, characterization, molecular docking, and biological activities of coumarin–1,2,3‐triazole‐acetamide hybrid derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000109
Abstract: Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin–1,2,3‐triazole‐acetamide hybrids was tested against some metabolic enzymes including α‐glycosidase (α‐Gly), α‐amylase (α‐Amy),… read more here.
Keywords: coumarin triazole; triazole acetamide; acetamide hybrids; metabolic enzymes ... See more keywords
In vitro inhibitory effects of some acetophenone derivatives on some metabolic enzymes and molecular docking
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DOI: 10.1002/ardp.202000210
Abstract: In this study, the acetophenone derivatives 1–6 were found to be effective inhibitor molecules for α‐glycosidase, human carbonic anhydrases I and II (hCA I/II), and acetylcholinesterase (AChE), with Ki values in the range of 167.98 ± 25.06… read more here.
Keywords: inhibitory effects; vitro inhibitory; acetophenone derivatives; pdb ... See more keywords
Design, synthesis, SAR, and biological evaluation of saccharin‐based hybrids as carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200019
Abstract: Saccharin is a cyclic secondary sulfonamide, which is a selective inhibitor of the tumor‐associated carbonic anhydrase (CA; EC 4.2.1.1) enzymes CA IX and CA XII compared to many primary sulfonamides. In this study, new saccharin‐1,2,3‐triazole… read more here.
Keywords: design synthesis; carbonic anhydrase; hca; hca hca ... See more keywords
Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200383
Abstract: In recent years, multistep hybrid computational protocols have attracted attention for their application in the drug discovery of enzyme inhibitors. So far, there are large collections of human carbonic anhydrase (hCA) inhibitors, but only a… read more here.
Keywords: human carbonic; sulfonamide based; carbonic anhydrase; hca ... See more keywords
Sulfonamide‐incorporated bis(α‐aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X‐ray crystallographic studies
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400038
Abstract: A novel series of sulfonamide‐incorporated bis(α‐aminophosphonates) acting as effective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors is reported. The synthesized bivalent ligands were tested against five human (h) isoforms, hCA I, hCA II, hCA VII, hCA… read more here.
Keywords: sulfonamide incorporated; hca; bis; hca hca ... See more keywords
Benzenesulfonamides functionalized with triazolyl‐linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400114
Abstract: The design and synthesis of a library of 21 novel benzenesulfonamide‐bearing 3‐functionalized pyrazole‐linked 1,2,3‐triazole derivatives as dual inhibitors of cathepsin B and carbonic anhydrase enzymes are reported. The target 1,2,3‐triazole‐linked pyrazolic esters (16) were synthesized… read more here.
Keywords: cathepsin carbonic; carbonic anhydrase; anhydrase; synthesized compounds ... See more keywords
Exploration of 3‐Substituted Benzofuran‐Tethered Sulfamoyl Triazoles as Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation
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DOI: 10.1002/cmdc.202500080
Abstract: This study reports the design and synthesis of benzofuran‐tethered sulfamoyl triazoles. These compounds are evaluated against two human carbonic anhydrases (hCA I and II) and three CAs from the bacterial pathogen mycobacterium TB (mtCA1–3). The… read more here.
Keywords: benzofuran tethered; sulfamoyl triazoles; hca; tethered sulfamoyl ... See more keywords
Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29884
Abstract: Genetic alterations define different molecular subclasses of hepatocellular adenoma (HCA) linked with risk factors, histology and clinical behavior. Recently, Argininosuccinate Synthase 1 (ASS1), a major periportal protein, was proposed as a marker of HCA with… read more here.
Keywords: sonic hedgehog; hca; expression; ass1 expression ... See more keywords
Vinyl functionalized 5,6‐dimethylbenzimidazolium salts: Synthesis and biological activities
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23255
Abstract: A series of vinyl functionalized 5,6‐dimethylbenzimidazolium salts are synthesized. All compounds were fully characterized by elemental analyses, MS, 1H‐NMR, 13C‐NMR, and IR spectroscopy techniques. Enzyme inhibition is a very active area of research in drug… read more here.
Keywords: salts synthesis; functionalized dimethylbenzimidazolium; vinyl functionalized; hca ... See more keywords