Synthesis and characterization of some new pyrazolines and their inhibitory potencies against carbonic anhydrases
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900292
Abstract: The inhibition of the two human cytosolic carbonic anhydrase (hCA; EC 4.2.1.1) isozymes I and II with some new pyrazoline derivatives was investigated for the first time. The structures of the newly synthesized pyrazoline derivatives… read more here.
Keywords: new pyrazolines; inhibitory potencies; characterization new; hca ... See more keywords
Synthesis, characterization, molecular docking, and biological activities of coumarin–1,2,3‐triazole‐acetamide hybrid derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000109
Abstract: Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin–1,2,3‐triazole‐acetamide hybrids was tested against some metabolic enzymes including α‐glycosidase (α‐Gly), α‐amylase (α‐Amy),… read more here.
Keywords: coumarin triazole; triazole acetamide; acetamide hybrids; metabolic enzymes ... See more keywords
In vitro inhibitory effects of some acetophenone derivatives on some metabolic enzymes and molecular docking
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DOI: 10.1002/ardp.202000210
Abstract: In this study, the acetophenone derivatives 1–6 were found to be effective inhibitor molecules for α‐glycosidase, human carbonic anhydrases I and II (hCA I/II), and acetylcholinesterase (AChE), with Ki values in the range of 167.98 ± 25.06… read more here.
Keywords: inhibitory effects; vitro inhibitory; acetophenone derivatives; pdb ... See more keywords
Design, synthesis, SAR, and biological evaluation of saccharin‐based hybrids as carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200019
Abstract: Saccharin is a cyclic secondary sulfonamide, which is a selective inhibitor of the tumor‐associated carbonic anhydrase (CA; EC 4.2.1.1) enzymes CA IX and CA XII compared to many primary sulfonamides. In this study, new saccharin‐1,2,3‐triazole… read more here.
Keywords: design synthesis; carbonic anhydrase; hca; hca hca ... See more keywords
Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200383
Abstract: In recent years, multistep hybrid computational protocols have attracted attention for their application in the drug discovery of enzyme inhibitors. So far, there are large collections of human carbonic anhydrase (hCA) inhibitors, but only a… read more here.
Keywords: human carbonic; sulfonamide based; carbonic anhydrase; hca ... See more keywords
Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29884
Abstract: Genetic alterations define different molecular subclasses of hepatocellular adenoma (HCA) linked with risk factors, histology and clinical behavior. Recently, Argininosuccinate Synthase 1 (ASS1), a major periportal protein, was proposed as a marker of HCA with… read more here.
Keywords: sonic hedgehog; hca; expression; ass1 expression ... See more keywords
Vinyl functionalized 5,6‐dimethylbenzimidazolium salts: Synthesis and biological activities
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23255
Abstract: A series of vinyl functionalized 5,6‐dimethylbenzimidazolium salts are synthesized. All compounds were fully characterized by elemental analyses, MS, 1H‐NMR, 13C‐NMR, and IR spectroscopy techniques. Enzyme inhibition is a very active area of research in drug… read more here.
Keywords: salts synthesis; functionalized dimethylbenzimidazolium; vinyl functionalized; hca ... See more keywords
Response to “Quantitative analysis of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of llcer method using gadobenate dimeglumine as contrast agent”
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25788
Abstract: We read with interest the letter that the editor of JMRI received regarding our article, “Differentiation of focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA): Role of the quantitative analysis of gadobenate dimeglumine-enhanced hepatobiliary phase… read more here.
Keywords: fnh; llcer; method; nodular hyperplasia ... See more keywords
Subtyping of hepatocellular adenoma: a machine learning-based approach
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DOI: 10.1007/s00428-022-03311-w
Abstract: Subtyping of hepatocellular adenoma (HCA) is an important task in practice as different subtypes may have different clinical outcomes and management algorithms. Definitive subtyping is currently dependent on immunohistochemical and molecular testing. The association between… read more here.
Keywords: morphologic clinical; subtyping hepatocellular; machine; hepatocellular adenoma ... See more keywords
Identification of simple sequence repeat markers for sweetpotato weevil resistance
Sign Up to like & getrecommendations! Published in 2017 at "Euphytica"
DOI: 10.1007/s10681-017-1917-1
Abstract: The development of sweetpotato [Ipomoea batatas (L.) Lam] germplasm with resistance to sweetpotato weevil (SPW) requires an understanding of the biochemical and genetic mechanisms of resistance to optimize crop resistance. The African sweetpotato landrace, ‘New… read more here.
Keywords: weevil resistance; spw; resistance; sweetpotato weevil ... See more keywords
Elucidating the dechlorination mechanism of hexachloroethane by Pd-doped zerovalent iron microparticles in dissolved lactic acid polymers using chromatography and indirect monitoring of iron corrosion
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-04128-y
Abstract: The degradation mechanism of the pollutant hexachloroethane (HCA) by a suspension of Pd-doped zerovalent iron microparticles (Pd-mZVI) in dissolved lactic acid polymers and oligomers (referred to as PLA) was investigated using gas chromatography and the… read more here.
Keywords: mechanism; pla; hca; iron corrosion ... See more keywords