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   Articles with "hcc" as a keyword



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Association Between Aspirin Use and Risk of Hepatocellular Carcinoma

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recommendations! Published in 2018 at "JAMA Oncology"

DOI: 10.1001/jamaoncol.2018.4154

Abstract: Importance Prospective data on the risk of hepatocellular carcinoma (HCC) according to dose and duration of aspirin therapy are limited. Objective To examine the potential benefits of aspirin use for primary HCC prevention at a… read more here.

Keywords: risk; hcc; use; aspirin use ... See more keywords
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hnRNPU Functions as a Novel Therapeutic Target of c-Myc in the Progression of Hepatocellular Carcinoma.

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recommendations! Published in 2020 at "FEBS letters"

DOI: 10.1002/1873-3468.13943

Abstract: Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is… read more here.

Keywords: hepatocellular carcinoma; hnrnpu functions; hcc; target ... See more keywords

Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6‐independent manner

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recommendations! Published in 2017 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12072

Abstract: Palbociclib, a CDK4/6 inhibitor, has recently been approved for hormone receptor‐positive breast cancer patients. The effects of palbociclib as a treatment for other malignancies, including hepatocellular carcinoma (HCC), are of great clinical interest and are… read more here.

Keywords: hepatocellular carcinoma; palbociclib; hcc; pp5 ampk ... See more keywords
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lncRNA‐PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12553

Abstract: Hepatocellular carcinoma (HCC) is a malignancy with one of the worst prognoses. Long noncoding RNA (lncRNA) are emerging as an important regulator of gene expression and function, leading to the development of cancer. The aim… read more here.

Keywords: hepatocellular carcinoma; hcc; pdpk2p; lncrna pdpk2p ... See more keywords
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Serum small extracellular vesicle‐derived LINC00853 as a novel diagnostic marker for early hepatocellular carcinoma

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12745

Abstract: This study aimed to identify novel long noncoding RNA (lncRNA) biomarkers for hepatocellular carcinoma (HCC) using publicly available tissue genomic datasets and validate their diagnostic utility for early‐stage HCC. Differentially expressed lncRNAs between 371 HCC… read more here.

Keywords: hepatocellular carcinoma; extracellular vesicle; hcc; derived linc00853 ... See more keywords
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Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1‐CX3CR1 dependent manner and induce tumour cell apoptosis

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12783

Abstract: The mechanisms and biological functions of migrating platelets in cancer remain largely unknown. Here, we analyzed platelet infiltration in hepatocellular carcinoma. We detected platelet extravasation in both mouse and human HCC tissues. CX3CL1 directly induced… read more here.

Keywords: hepatocellular carcinoma; hcc; platelet migration; cell apoptosis ... See more keywords
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BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma

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recommendations! Published in 2021 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12963

Abstract: The malignant nature of hepatocellular carcinoma (HCC) is closely related to the presence of cancer stem cells (CSCs). Bone morphologic protein 9 (BMP9), a member of the transforming growth factor‐beta (TGF‐β) superfamily, was recently reported… read more here.

Keywords: epcam positive; hcc; id1 signaling; cancer ... See more keywords
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Precision N-glycoproteomics reveals elevated LacdiNAc as a novel signature of intrahepatic cholangiocarcinoma.

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recommendations! Published in 2021 at "Molecular oncology"

DOI: 10.1002/1878-0261.13147

Abstract: Primary liver cancer, mainly comprising hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), remains a major global health problem. Although ICC is clinically different from HCC, their molecular differences are still largely unclear. In this study,… read more here.

Keywords: precision; hcc; icc hcc; intrahepatic cholangiocarcinoma ... See more keywords
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A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α‐mediated aerobic glycolysis

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13211

Abstract: Hepatocellular carcinoma (HCC) is characterized by rapid growth, early vascular invasion, and high metastasis. Currently available US Food and Drug Administration (FDA)‐approved drugs show low therapeutic efficacy, limiting HCC treatment to chemotherapy. We designed and… read more here.

Keywords: hif1; hcc; aerobic glycolysis; sct 1015 ... See more keywords
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Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13263

Abstract: In hepatocellular carcinoma (HCC), the signal transducer and activator of transcription 3 (STAT3) is present in an overactive state that is closely related to tumour development and immune escape. STAT3 inhibition reshapes the tumour immune… read more here.

Keywords: cell death; cell; inhibition; hcc ... See more keywords
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Mammalian‐enabled (MENA) protein enhances oncogenic potential and cancer stem cell‐like phenotype in hepatocellular carcinoma cells

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12254

Abstract: Mammalian‐enabled (MENA) protein is an actin‐regulatory protein that influences cell motility and adhesion. It is known to play a role in tumorigenicity of hepatocellular carcinoma (HCC) but the underlying molecular mechanism remains unknown. This study… read more here.

Keywords: protein; hcc; hcc cells; stem cell ... See more keywords