NEIL3 Deficiency Enhances HCC Cell Sensitivity to Oxaliplatin by Inhibiting the Fanconi Anaemia Pathway
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DOI: 10.1002/cbin.70023
Abstract: Despite some achievements in oxaliplatin‐based chemotherapy for the treatment of advanced hepatocellular carcinoma (HCC), the abnormal activation of DNA damage repair pathways in HCC cells remains a major problem, limiting the efficacy of oxaliplatin‐based chemotherapy.… read more here.
Keywords: fanconi anaemia; anaemia pathway; hcc cell; efficacy ... See more keywords
Depletion of TRRAP Induces p53‐Independent Senescence in Liver Cancer by Down‐Regulating Mitotic Genes
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DOI: 10.1002/hep.30807
Abstract: Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer with few effective treatments, and the underlying mechanisms that drive HCC pathogenesis remain poorly characterized. Identifying genes and pathways essential for HCC cell growth will… read more here.
Keywords: trrap; hcc cell; cancer; mitotic genes ... See more keywords
Activation of EGFR‐KLF4 positive feedback loop results in acquired resistance to sorafenib in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23102
Abstract: Sorafenib is the standard first‐line systemic chemotherapeutic drugs for advanced hepatocellular carcinoma (HCC), but acquired resistance to sorafenib is frequently observed in clinical practice. In this study, we first produced three sorafenib resistance (SR) HCC… read more here.
Keywords: positive feedback; hcc; feedback loop; sorafenib ... See more keywords
ADAM9 mediates the interleukin-6-induced Epithelial-Mesenchymal transition and metastasis through ROS production in hepatoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.02.010
Abstract: Interleukin (IL)-6 has been implicated in the invasion and metastasis of hepatocellular carcinoma (HCC). However, the molecular events that mediate this process are poorly understood. Here, we showed that IL-6 promoted the epithelial-mesenchymal transition (EMT)… read more here.
Keywords: mesenchymal transition; hcc; metastasis; hcc cell ... See more keywords
Berbamine (BBM), a Natural STAT3 Inhibitor, Synergistically Enhances the Antigrowth and Proapoptotic Effects of Sorafenib on Hepatocellular Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03527
Abstract: Sorafenib (SORA), a multi kinase inhibitor, is the standard first-line targeted therapy approved by the Food and Drug Administration for advanced hepatocellular carcinoma (HCC). However, emerging evidence from clinical practice indicates that SORA alone has… read more here.
Keywords: hepatocellular carcinoma; hcc; cell lines; stat3 ... See more keywords
Molecular docking analysis of some medicinal extracts for pro-apoptotic, antiinflammatory and antioxidative activities using HCC cell lines.
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DOI: 10.1080/14786419.2024.2383265
Abstract: Abstract We investigated the biological activities of 14 medicinal plants from Saudi Arabia as anti-inflammatory, antioxidant and anti-proliferative properties using hepatocellular carcinoma (HCC) cell lines. Hexane extracts exhibited the maximum inhibitory activities against albumin denaturation… read more here.
Keywords: cell lines; extract showed; hcc cell; cell ... See more keywords
Hepatic stellate cell‐released CXCL1 aggravates HCC malignant behaviors through the MIR4435‐2HG/miR‐506‐3p/TGFB1 axis
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DOI: 10.1111/cas.15605
Abstract: Hepatic stellate cell (HSC) activation is a critical event in the development of hepatic fibrosis and hepatocellular carcinoma (HCC). By the release of soluble cytokines, chemokines, and chemotaxis, HSCs affect HCC cell phenotypes through a… read more here.
Keywords: mir 506; hcc cell; hcc; mir4435 2hg ... See more keywords
Abstract 3517: Targeting pH regulators to modulate human hepatocellular carcinoma microenvironment
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DOI: 10.1158/1538-7445.am2018-3517
Abstract: Hepatocellular carcinoma (HCC) arises in a hypoxic/acidic microenvironment in which the pO2 is about 0.8%. This condition favors tumor progression and fosters immunosuppression. Tumor cells survive this obstile environment by overexpressing pH regulators such as… read more here.
Keywords: hepatocellular carcinoma; microenvironment; hcc; atpase ... See more keywords
LncRNA HOXD-AS1 promotes the metastasis of human hepatocellular carcinoma via modulating miR-326/SLC27A4
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DOI: 10.1186/s12935-020-01217-8
Abstract: Background Mounting evidences have indicated that long non-coding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) is dysregulated and participates into the progression of cancers. This study aims to investigate the biological roles and mechanisms… read more here.
Keywords: mir 326; hcc cell; as1; hoxd as1 ... See more keywords
Gly-tRF enhances LCSC-like properties and promotes HCC cells migration by targeting NDFIP2
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DOI: 10.1186/s12935-021-02102-8
Abstract: Background Accumulating evidence demonstrates that tRFs (tRNA-derived small RNA fragments) and tiRNAs (tRNA-derived stress-induced RNA), an emerging category of regulatory RNA molecules derived from transfer RNAs (tRNAs), are dysregulated in in various human cancer types… read more here.
Keywords: hcc; migration; hcc cell; gly trf ... See more keywords
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
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DOI: 10.1186/s13062-024-00475-0
Abstract: Background Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC). OTU deubiquitinase 5 (OTUD5), a DUB family member, has… read more here.
Keywords: hcc; stabilizing slc38a1; deubiquitinating stabilizing; hcc cell ... See more keywords