Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression
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DOI: 10.1038/s41598-020-67425-4
Abstract: Transcription factor ERG (erythroblast transformation-specific (ETS)-related gene) is essential in endothelial differentiation and angiogenesis, in which microRNA (miR)-200b-3p targeting site is expected by miRNA target prediction database. miR-200b is known decreased in hepatocellular carcinoma (HCC),… read more here.
Keywords: hcc; endothelial erg; mir 200b; hcc tissues ... See more keywords
Increased Expression of Programmed Death-Ligand 1 in Infiltrating Immune Cells in Hepatocellular Carcinoma Tissues after Sorafenib Treatment
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DOI: 10.1159/000489021
Abstract: Objective: Programmed death-ligand 1 (PD-L1) expression in the tumor microenvironment (TME) has been reported to be related to prognosis in patients with hepatocellular carcinoma (HCC) after hepatectomy. The impact of sorafenib on PD-L1 expression in… read more here.
Keywords: sorafenib treatment; post sorafenib; sorafenib; hcc tissues ... See more keywords
CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment
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DOI: 10.3389/fcell.2021.681372
Abstract: Immunosuppressive tumor microenvironment in hepatocellular carcinoma (HCC) is critical in tumor development. C-type (Ca2+ -dependent) lectin (CLEC) receptors, essential in innate pattern recognition, have potential regulatory effects on immune cell trafficking and modulatory effects on… read more here.
Keywords: hepatocellular carcinoma; microenvironment; hcc; hcc tissues ... See more keywords
A Critical YAP in Malignancy of HCC Is Regulated by Evodiamine
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DOI: 10.3390/ijms23031855
Abstract: Liver cancer has relatively few early symptoms and is usually diagnosed in the advanced stage. Sorafenib is the only first-line anticancer drug approved by the Food and Drug Administration (FDA) for advanced HCC; however, its… read more here.
Keywords: hcc tissues; critical yap; hcc; malignancy hcc ... See more keywords
MicroRNA‑466 inhibits the aggressive behaviors of hepatocellular carcinoma by directly targeting metadherin.
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DOI: 10.3892/or.2018.6763
Abstract: Numerous microRNAs (miRNAs) have been demonstrated to be downregulated or upregulated in hepatocellular carcinoma (HCC) and play important roles in its occurrence and development. Therefore, the investigation of miRNAs and their functions implicated in the… read more here.
Keywords: hepatocellular carcinoma; hcc; mir 466; hcc cells ... See more keywords
ZNF521 which is downregulated by miR-802 suppresses malignant progression of Hepatocellular Carcinoma through regulating Runx2 expression
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DOI: 10.7150/jca.45190
Abstract: Zinc finger protein 521 (ZNF521) plays an important role in the tumor development and process. However, its regulatory role in hepatocellular carcinoma (HCC) remains unclear. In this study, we demonstrated for the first time that… read more here.
Keywords: hepatocellular carcinoma; znf521; mir 802; hcc tissues ... See more keywords