Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway
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DOI: 10.1042/bsr20160478
Abstract: Recent evidence supports a role for microRNA-223 (miR-223) in modulating tumor cell sensitivity to chemotherapeutic drugs; however, its role in cellular resistance to the effects of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) used… read more here.
Keywords: hcc827 cells; hcc827; erlotinib; expression ... See more keywords
Abstract 548: Histone deacetylase inhibitor, Vorinostat, reverses EGFR-TKI resistance in lung adenocarcinoma via degradation of MET
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DOI: 10.1158/1538-7445.am2025-548
Abstract: Epidermal growth factor receptor (EGFR) mutations occur in 15-50% of patients worldwide with lung adenocarcinoma (LUAD). While tyrosine kinase inhibitors (TKIs) that directly target activating EGFR mutations prolong the survival of these LUAD patients, most… read more here.
Keywords: hcc827; resistance; treatment; degradation ... See more keywords