Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence.
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DOI: 10.1021/acs.jmedchem.1c01965
Abstract: Human carboxylesterase 2 (hCES2) converts anticancer prodrugs, such as irinotecan, into their active metabolites via phase I drug metabolism. Owing to interindividual variability, hCES2 serves as a predictive marker of patient response to hCES2-activated prodrug-based… read more here.
Keywords: two photon; carboxylesterase; activity; hces2 ... See more keywords