Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.03.006
Abstract: Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-intrinsic oncogene. Here we find that high HCK levels correlate with reduced survival of colorectal cancer patients. Likewise,… read more here.
Keywords: kinase; hematopoietic cell; hck; cancer ... See more keywords
Conversion of V-porphyrin in asphaltenes into V2S3 as an active catalyst for slurry phase hydrocracking of vacuum residue
Sign Up to like & getrecommendations! Published in 2020 at "Fuel"
DOI: 10.1016/j.fuel.2019.116620
Abstract: Abstract The asphaltene hydrocracking (HCK) was carried out at 693 K and 11.0 MPa H2 to examine the phase transformation of V species contained in the asphaltene and the catalytic activity of the resulting V compounds in… read more here.
Keywords: porphyrin asphaltenes; phase; vacuum residue; conversion ... See more keywords
Cocrystallization of the Src-Family Kinase Hck with the ATP-Site Inhibitor A-419259 Stabilizes an Extended Activation Loop Conformation
Sign Up to like & getrecommendations! Published in 2024 at "Biochemistry"
DOI: 10.1021/acs.biochem.4c00323
Abstract: Hematopoietic cell kinase (Hck) is a member of the Src kinase family and is a promising drug target in myeloid leukemias. Here, we report the crystal structure of human Hck in complex with the pyrrolopyrimidine… read more here.
Keywords: conformation; site; inhibitor; activation loop ... See more keywords
Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00288
Abstract: HIV-1 Nef is an attractive target for antiretroviral drug discovery because of its role in promoting HIV-1 infectivity, replication, and host immune system avoidance. Here, we applied a screening strategy in which recombinant HIV-1 Nef… read more here.
Keywords: hiv; replication; hck; hiv nef ... See more keywords
Abnormal HCK/glutamine/autophagy axis promotes endometriosis development by impairing macrophage phagocytosis
Sign Up to like & getrecommendations! Published in 2024 at "Cell Proliferation"
DOI: 10.1111/cpr.13702
Abstract: The presence of extensive infiltrated macrophages with impaired phagocytosis is widely recognised as a significant regulator for the development of endometriosis (EMs). Nevertheless, the metabolic characteristics and the fundamental mechanism of impaired macrophage phagocytosis are… read more here.
Keywords: macrophage phagocytosis; phagocytosis; macrophage; autophagy ... See more keywords
A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTKC481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-130636
Abstract: Activating mutations in MYD88 promote malignant cell growth and survival through multiple pathways that include BTK and HCK. HCK is transcriptionally upregulated and activated by mutated MYD88 and in turn activates BTK itself, as well… read more here.
Keywords: cell; kin 8194; hck; research funding ... See more keywords
Development and Characterization of Novel Dual HCK/BTK Bifunctional Protacs That Potently Inhibit Kinase Function and Demonstrate Robust in Vitro and In Vivo Degradation of Targets for the Treatment of MYD88-Mutated B-Cell Malignancies
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-211103
Abstract: Background: Activating mutations in MYD88 are prevalent in many B-cell malignancies, including Waldenström Macroglobulinemia (95-97%), primary CNS lymphoma (70-80%), ABC DLBCL (40%), marginal zone lymphoma (5-10%), and CLL (5-15%). Mutated MYD88 upregulates the SRC family… read more here.
Keywords: myd88 mutated; hck btk; btk; kinase ... See more keywords
A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006147
Abstract: Key Points HCK facilitates TLR/BCR crosstalk through activation of SYK in response to mutated MYD88. The HCK inhibitor A419259 selectively blocks SYK activation in MYD88 mutated cell lines and primary WM lymphoplasmacytic cells. read more here.
Keywords: hck; syk activation; myd88 mutated; activation myd88 ... See more keywords
Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21082682
Abstract: Runx2 is required for chondrocyte proliferation and maturation. In the search of Runx2 target genes in chondrocytes, we found that Runx2 up-regulated the expression of hematopoietic cell kinase (Hck), which is a member of the… read more here.
Keywords: runx2; expression; hck; chondrocyte proliferation ... See more keywords