A randomised, double blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001638
Abstract: Preclinical studies suggest that type 2 hyperpolarization-activated cyclic nucleotide gated ion channels (HCN2) are necessary for neuropathic pain. This trial assessed the influence of ivabradine, a non-selective HCN channel blocker, on capsaicin-induced hyperalgesia and pain… read more here.
Keywords: trial; hcn channel; channel blocker; placebo ... See more keywords
HCN channels in the hippocampus regulate active coping behavior
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14539
Abstract: Active coping is an adaptive stress response that improves outcomes in medical and neuropsychiatric diseases. To date, most research into coping style has focused on neurotransmitter activity and little is known about the intrinsic excitability… read more here.
Keywords: coping behavior; active coping; coping style; hcn channels ... See more keywords
HCN Channel Modulation of Synaptic Integration in GABAergic Interneurons in Malformed Rat Neocortex
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00109
Abstract: Cortical malformations are often associated with pharmaco-resistant epilepsy. Alterations in hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels have been shown to contribute to malformation associated hyperexcitability. We have recently demonstrated that expression of HCN channels… read more here.
Keywords: fast spiking; malformed rat; control; hcn ... See more keywords
Depolarization and Hyperexcitability of Cortical Motor Neurons after Spinal Cord Injury Associates with Reduced HCN Channel Activity
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054715
Abstract: A spinal cord injury (SCI) damages the axonal projections of neurons residing in the neocortex. This axotomy changes cortical excitability and results in dysfunctional activity and output of infragranular cortical layers. Thus, addressing cortical pathophysiology… read more here.
Keywords: cord injury; hcn channel; injury; activity ... See more keywords
HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.42766
Abstract: Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control electrical rhythmicity and excitability in the heart and brain, but the function of HCN channels at the subcellular level in axons remains poorly understood. Here, we show that the action… read more here.
Keywords: velocity; control; hcn channel; central axons ... See more keywords