"Funny" channels in cardiac mitochondria modulate membrane potential and oxygen consumption.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.033
Abstract: The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by a family of four genes (HCN1-4). All isoforms are expressed in the heart, HCN4 being the most abundant in the sinoatrial node (SAN). HCN channels are… read more here.
Keywords: mitochondria; hcn channels; oxygen consumption; membrane potential ... See more keywords
Investigating Ligand Binding to HCN Channels by Surface Plasmon Resonance
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.252
Abstract: Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control cardiac and neuronal rhythmicity. HCN channels contain cyclic nucleotide-binding (CNB) domain in their C-terminal region linked to the pore-forming transmembrane segment with a C-linker. The C-linker couples the conformational… read more here.
Keywords: linker cnb; ligand binding; hcn channels; linker ... See more keywords
Photodynamic modification of native HCN channels expressed in thalamocortical neurons.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00475
Abstract: The photodynamic process requires three elements: light, oxygen, and photosensitizer. The process involves the formation of singlet oxygen which is the molecular oxygen in excited electronic states. Previously, we reported that heterologously expressed hyperpolarization-activated cAMP-gated… read more here.
Keywords: channels expressed; hcn; hcn channels; native hcn ... See more keywords
An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15791-y
Abstract: During high-frequency network activities, fast-spiking, parvalbumin-expressing basket cells (PV + -BCs) generate barrages of fast synaptic inhibition to control the probability and precise timing of action potential (AP) initiation in principal neurons. Here we describe… read more here.
Keywords: expression hcn; specific expression; hcn; hcn channels ... See more keywords
HCN channels in the hippocampus regulate active coping behavior
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14539
Abstract: Active coping is an adaptive stress response that improves outcomes in medical and neuropsychiatric diseases. To date, most research into coping style has focused on neurotransmitter activity and little is known about the intrinsic excitability… read more here.
Keywords: coping behavior; active coping; coping style; hcn channels ... See more keywords
Theta resonance and synaptic modulation scale activity patterns in the medial entorhinal cortex stellate cells
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14434
Abstract: Stellate cells (SCs) of the medial entorhinal cortex (MEC) are rich in hyperpolarization‐activated cyclic nucleotide–gated (HCN) channels, which are known to effectively shape their activity patterns. The explanatory mechanisms, however, have remained elusive. One important… read more here.
Keywords: modulation; entorhinal cortex; activity patterns; hcn channels ... See more keywords
HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002001
Abstract: Accumulating evidence indicates that there are substantial species differences in the properties of mammalian neurons, yet theories on circuit activity and information processing in the human brain are based heavily on results obtained from rodents… read more here.
Keywords: hcn channels; fast spiking; cell soma; membrane ... See more keywords
HCN channels in the heart.
Sign Up to like & getrecommendations! Published in 2022 at "Current cardiology reviews"
DOI: 10.2174/1573403x18666220204142436
Abstract: Pacemaker cells are the basis of rhythm in life. Cardiovascular diseases, and in particular, arrhythmias, are a leading cause of hospital admissions and have been implicated as a cause of sudden death. The prevalence of… read more here.
Keywords: pharmacology; hyperpolarization; heart; hcn channels ... See more keywords
Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion (HCN) Channels Regulate PC12 Cell Differentiation Toward Sympathetic Neuron
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00415
Abstract: Hyperpolarization-activated cyclic nucleotide-gated ion channels (HCN channels) are widely expressed in the central and peripheral nervous systems and organs, while their functions are not well elucidated especially in the sympathetic nerve. The present study aimed… read more here.
Keywords: pc12 cells; sympathetic neuron; differentiation; hcn channels ... See more keywords
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00141
Abstract: Neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA) are chronic, progressive, and age-associated neurological disorders characterized by neuronal deterioration in specific brain regions. Although… read more here.
Keywords: neurodegenerative diseases; activated cyclic; hcn channels; hyperpolarization activated ... See more keywords
Corrigendum: Validation of the binding stoichiometry between HCN channels and their neuronal regulator TRIP8b by single molecule measurements
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1211400
Abstract: [This corrects the article DOI: 10.3389/fphys.2022.998176.]. read more here.
Keywords: binding stoichiometry; channels neuronal; validation binding; stoichiometry hcn ... See more keywords