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Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17447
Abstract: Acquisition of drugâsensitivity profiles is challenging in rare epilepsies. Anecdotal evidence suggests that antiseizure medications that block sodium channels as their primary mechanism of action exacerbate seizures in HCN1 developmental and epileptic encephalopathies (DEEs), whereas…
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Keywords:
hcn1 developmental;
hcn1;
developmental epileptic;
efficacy ... See more keywords
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Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.848540
Abstract: Cannabinoids are a broad class of molecules that act primarily on neurons, affecting pain sensation, appetite, mood, learning, and memory. In addition to interacting with specific cannabinoid receptors (CBRs), cannabinoids can directly modulate the function…
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Keywords:
hcn1;
activated cyclic;
hcn1 channels;
hyperpolarization activated ... See more keywords
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Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.870182
Abstract: Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel plays a critical role in regulating the resting membrane potential and integrating synaptic transmission. Variants of HCN1 have been recognized as causes of epilepsy, and mutant HCN1 channels could act…
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Keywords:
pathogenic variants;
function;
hcn1;
novel hcn1 ... See more keywords