Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy
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DOI: 10.1111/epi.17447
Abstract: Acquisition of drugâsensitivity profiles is challenging in rare epilepsies. Anecdotal evidence suggests that antiseizure medications that block sodium channels as their primary mechanism of action exacerbate seizures in HCN1 developmental and epileptic encephalopathies (DEEs), whereas… read more here.
Keywords: hcn1 developmental; hcn1; developmental epileptic; efficacy ... See more keywords
Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids
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DOI: 10.3389/fnmol.2022.848540
Abstract: Cannabinoids are a broad class of molecules that act primarily on neurons, affecting pain sensation, appetite, mood, learning, and memory. In addition to interacting with specific cannabinoid receptors (CBRs), cannabinoids can directly modulate the function… read more here.
Keywords: hcn1; activated cyclic; hcn1 channels; hyperpolarization activated ... See more keywords
Novel HCN1 Mutations Associated With Epilepsy and Impacts on Neuronal Excitability
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DOI: 10.3389/fnmol.2022.870182
Abstract: Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel plays a critical role in regulating the resting membrane potential and integrating synaptic transmission. Variants of HCN1 have been recognized as causes of epilepsy, and mutant HCN1 channels could act… read more here.
Keywords: pathogenic variants; function; hcn1; novel hcn1 ... See more keywords