Una variente rara en HCN4 produce un fenotipo de hipertrabeculación/no compactación ventricular, dilatación auricular izquierda y bradicardia sinusal
Sign Up to like & getrecommendations! Published in 2020 at "Revista Espanola De Cardiologia"
DOI: 10.1016/j.recesp.2020.06.037
Abstract: Resumen Introduccion y objetivos Se han descrito previamente variantes geneticas del gen HCN4 con el fenotipo combinado de sindrome del seno enfermo (SSE) y miocardiopatia no compactada del ventriculo izquierdo (MCNC). Actualmente hay pocos casos… read more here.
Keywords: dai; mcnc; genetica; con ... See more keywords
Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22737-5
Abstract: Endogenous cardiac pacemaker function regulates the rate and rhythm of cardiac contraction. The mutation p.Lys23Glu in the cohesin protein Shugoshin-1 causes severe heart arrhythmias due to sinoatrial node dysfunction and a debilitating gastrointestinal motility disorder,… read more here.
Keywords: pacemaker; channel; protein shugoshin; cohesin protein ... See more keywords
Promotion of Differentiating Bone Marrow Mesenchymal Stromal Cells (BMSCs) into Cardiomyocytes via HCN2 and HCN4 Cotransfection
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/5529276
Abstract: Aim Investigation of the influences HCN2 and HCN4 has on bone marrow mesenchymal stromal cells (BMSCs) on cardiomyocyte differentiation. Methods Miniature adult pigs were used for bone marrow extraction and isolation of BMSCs. The identification… read more here.
Keywords: hcn4; hcn2 hcn4; bone marrow;
Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia
Sign Up to like & getrecommendations! Published in 2017 at "Circulation Research"
DOI: 10.1161/circresaha.117.311607
Abstract: Rationale: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, If, underlies exercise training–induced sinus bradycardia in rodents. If this occurs in humans, it could explain… read more here.
Keywords: channel; mir 423; bradycardia; hcn4 ... See more keywords
HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner
Sign Up to like & getrecommendations! Published in 2017 at "Biology Open"
DOI: 10.1242/bio.025957
Abstract: ABSTRACT Laterality is a basic characteristic of all life forms, from single cell organisms to complex plants and animals. For many metazoans, consistent left-right asymmetric patterning is essential for the correct anatomy of internal organs,… read more here.
Keywords: left right; right patterning; expression; nodal lefty ... See more keywords
Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1163339
Abstract: The sinoatrial node (SAN) and subsidiary pacemakers in the cardiac conduction system generate spontaneous electrical activity which is indispensable for electrical and therefore contractile function of the heart. The hyperpolarisation-activated cyclic nucleotide-gated channel HCN4 is… read more here.
Keywords: mediated currents; hcn4 mediated; magnitude hcn4; amino terminus ... See more keywords
Clinical Presentation of Left Ventricular Noncompaction Cardiomyopathy and Bradycardia in Three Families Carrying HCN4 Pathogenic Variants
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13030477
Abstract: Background: Left ventricular noncompaction (LVNC) is a genetically and phenotypically heterogeneous cardiomyopathy in which myocardium consists of two, distinct compacted and noncompacted layers, and prominent ventricular trabeculations and deep intertrabecular recesses are present. LVNC is… read more here.
Keywords: pathogenic variants; ventricular noncompaction; presentation; sinus bradycardia ... See more keywords
A Novel Flow Cytometry-Based Assay for the Identification of HCN4 CNBD Ligands
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16050710
Abstract: Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are promising therapeutic targets because of their association with the genesis of several diseases. The identification of selective compounds that alter cAMP-induced ion channel modulation by binding to the… read more here.
Keywords: ligand binding; camp; hcn4 cnbd; hcn4 ... See more keywords