Vapourized hydrogen peroxide decontamination in a hospital setting inactivates SARS-CoV-2 and HCoV-229E without compromising filtration efficiency of unexpired N95 respirators
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Infection Control"
DOI: 10.1016/j.ajic.2021.07.012
Abstract: Background The COVID-19 pandemic highlighted the need for evidence-based approaches to decontamination and reuse of N95 filtering facepiece respirators (FFRs). We sought to determine whether vapourized hydrogen peroxide (VHP) reduced SARS-CoV-2 bioburden on FFRs without… read more here.
Keywords: hcov 229e; sars cov; filtration efficiency; decontamination ... See more keywords
Interaction of cyclophilin a and human coronavirus 229E N protein is essential for virus replication.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104620
Abstract: The well-known immunosuppressive drug cyclosporin A inhibits replication of various viruses including coronaviruses by binding to cellular cyclophilins thus inactivating their cis-trans peptidyl-prolyl isomerase function. Viral nucleocapsid proteins are inevitable for genome encapsidation and replication.… read more here.
Keywords: protein; cyclophilin; csa derivatives; interaction ... See more keywords
Structural characterization of the HCoV-229E fusion core
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2018.02.136
Abstract: Abstract HCoV-229E spike (S) protein mediates virion attachment to cells and subsequent fusion of the viral and cellular membranes. This protein is composed of an N-terminal receptor-binding domain (S1) and a C-terminal trans-membrane fusion domain… read more here.
Keywords: fusion core; 229e fusion; fusion; structural characterization ... See more keywords
Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Phytomedicine"
DOI: 10.1016/j.phymed.2020.153296
Abstract: Abstract Background : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has extensively and rapidly spread in the world, causing an outbreak of acute infectious pneumonia. However, no specific antiviral drugs or vaccines can be used.… read more here.
Keywords: anti inflammatory; coronavirus; hcov 229e; sars cov ... See more keywords
Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.11.025
Abstract: Abstract Structure predictions suggest a partial conservation of RNA structure elements in coronavirus terminal genome regions. Here, we determined the structures of stem-loops (SL) 1 and 2 of two alphacoronaviruses, human coronavirus (HCoV) 229E and… read more here.
Keywords: terminal genome; conservation; hcov 229e; elements coronavirus ... See more keywords
Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202820120
Abstract: Significance Human coronavirus 229E(HCoV-229E) and NL63 (HCoV-NL63) are endemic worldwide and cause mild upper respiratory infections or occasionally, more severe lower respiratory tract infections. Mice are not permissive to these virus infections primarily because they… read more here.
Keywords: hcov nl63; hcov; mouse models; hcov 229e ... See more keywords
In vitro antiviral effect of Mexican and Brazilian propolis and phenolic compounds against human coronavirus 229E.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of environmental health research"
DOI: 10.1080/09603123.2022.2110576
Abstract: Propolis is a resinous substance collected by bees (Apis mellifera). It is used for its biological properties. This natural product is available as a safe therapeutic option. Herein, we report the antiviral effects of brown… read more here.
Keywords: effect mexican; antiviral effect; propolis; hcov 229e ... See more keywords
Transmission Dynamics of Respiratory Viruses in a Congregated Military Population: Prospective Cohort Study
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx163.503
Abstract: Abstract Background Human coronaviruses (HCoVs), rhinoviruses, and non-polio enteroviruses (NPEVs) are leading causes of seasonal acute respiratory infections among children and adults, posing significant health and economic burden annually. Despite this, little is known about… read more here.
Keywords: transmission; respiratory viruses; rhinoviruses npevs; hcov 229e ... See more keywords
Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00819-20
Abstract: Since its first appearance in the 1960s, the genetic diversity and evolution of human coronavirus 229E (HCoV-229E) have been relatively understudied. In this study, we report a fatal case of COVID-19 coinfected with HCoV-229E in… read more here.
Keywords: human coronavirus; hcov 229e; hcov; coronavirus 229e ... See more keywords
Robust Evaluation of Ultraviolet-C Sensitivity for SARS-CoV-2 and Surrogate Coronaviruses
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00537-21
Abstract: Disinfection of SARS-CoV-2 is of particular importance due to the global COVID-19 pandemic. UV-C irradiation is a compelling disinfection technique because it can be applied to surfaces, air, and water and is commonly used in… read more here.
Keywords: hcov 229e; sensitivity sars; sensitivity; sars cov ... See more keywords
Evaluation of compressed sodium chloride on the inactivation of SARS-CoV-2 and surrogates
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277881
Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the global COVID-19 pandemic. Limited studies have been performed on various types of disinfectants utilized to control the spread of this highly contagious virus. This study aimed to… read more here.
Keywords: sodium chloride; inactivation sars; compressed sodium; hcov 229e ... See more keywords